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Virus Details


VHFID4991

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name STAT5B
HF Protein Name Signal transducer and activator of transcription 5B
HF Function STAT-5 promotes HPV viral replication through activation of the ATM DNA damage response
Uniprot ID P51692
Protein Sequence View Fasta Sequence
NCBI Gene ID 6777
Host Factor (HF) Name in Paper STAT-5
Gene synonyms N.A.
Ensemble Gene ID ENSG00000173757
Ensemble Transcript ENST00000293328
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000255, GO:0000978, GO:0000981, GO:0001077, GO:0001553, GO:0001779, GO:0003682, GO:0003700, GO:0004713, GO:0004871, GO:0005634, GO:0005654, GO:0005737, GO:0005829, GO:0006101, GO:0006103, GO:0006105, GO:0006107, GO:0006357, GO:0006549, GO:0006573, GO:0006600, GO:0006631, GO:0007259, GO:0007565, GO:0007595, GO:0019218, GO:0019221, GO:0019530, GO:0019915, GO:0030856, GO:0032355, GO:0032819, GO:0032825, GO:0032870, GO:0033077, GO:0035259, GO:0035723, GO:0038110, GO:0038111, GO:0040014, GO:0040018, GO:0042104, GO:0042448, GO:0043029, GO:0043066, GO:0045086, GO:0045579, GO:0045588, GO:0045647, GO:0045648, GO:0045931, GO:0045944, GO:0045954, GO:0046449, GO:0046543, GO:0046544, GO:0046983, GO:0048541, GO:0050729, GO:0060397, GO:0070670, GO:0071363, GO:0071364, GO:0097531,
MINT ID P51692
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 245590
PANTHER ID PTHR11801;PTHR11801:SF39
PDB ID(s) N.A.,
pfam ID PF00017, PF01017, PF02864, PF02865,
Drug Bank ID DB01254,
ChEMBL ID CHEMBL5817
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Human Papillomavirus 31
Virus Short Name HPV31
Order Unassigned
Virus Family Papillomaviridae
Virus Subfamily N.A.
Genus Alphapapillomavirus
Species Human papillomavirus 16
Host Human, monkeys
Cell Tropism Epithelial cells of skin, mucous membranes
Associated Disease Malignant tumours
Mode of Transmission Sexual, indirect and direct contact, auto-inoculation
VIPR DB link N.A.
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/121/papillomaviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Papillomaviridae

Publication Information

Paper Title The JAK-STAT transcriptional regulator, STAT-5, activates the ATM DNA damage pathway to induce HPV 31 genome amplification upon epithelial differentiation
Author's Name Shiyuan Hong, Laimonis A. Laimins
Journal Name PLOS Pathogens
Pubmed ID 23593005
Abstract High-risk human papillomavirus (HPV) must evade innate immune surveillance to establish persistent infections and to amplify viral genomes upon differentiation. Members of the JAK-STAT family are important regulators of the innate immune response and HPV proteins downregulate expression of STAT-1 to allow for stable maintenance of viral episomes. STAT-5 is another member of this pathway that modulates the inflammatory response and plays an important role in controlling cell cycle progression in response to cytokines and growth factors. Our studies show that HPV E7 activates STAT-5 phosphorylation without altering total protein levels. Inhibition of STAT-5 phosphorylation by the drug pimozide abolishes viral genome amplification and late gene expression in differentiating keratinocytes. In contrast, treatment of undifferentiated cells that stably maintain episomes has no effect on viral replication. Knockdown studies show that the STAT-5beta isoform is mainly responsible for this activity and that this is mediated through the ATM DNA damage response. A downstream target of STAT-5, the peroxisome proliferator-activated receptor gamma (PPARgamma) contributes to the effects on members of the ATM pathway. Overall, these findings identify an important new regulatory mechanism by which the innate immune regulator, STAT-5, promotes HPV viral replication through activation of the ATM DNA damage response.
Used Model HFKs cells
DOI 10.1371/journal.ppat.1003295