| Gene Name | TMC6 |
| HF Protein Name | Transmembrane channel-like protein 6 |
| HF Function | Host Restriction factor |
| Uniprot ID | Q7Z403 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 11322 |
| Host Factor (HF) Name in Paper | EVER1 |
| Gene synonyms | EVER1 EVIN1 |
| Ensemble Gene ID | ENSG00000141524 |
| Ensemble Transcript | ENST00000306591 [Q7Z403-2];ENST00000322914 [Q7Z403-1];ENST00000392467 [Q7Z403-1];ENST00000589553 [Q7Z403-4];ENST00000590602 [Q7Z403-1];ENST00000591436 [Q7Z403-3] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0005737, GO:0005783, GO:0005789, GO:0005794, GO:0005886, GO:0006811, GO:0016021, GO:0031965, GO:0035579, GO:0043312, GO:0070062, GO:0070821, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 226400 |
| PANTHER ID | N.A. |
| PDB ID(s) | N.A., |
| pfam ID | PF07810, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Human Papillomavirus 31 |
| Virus Short Name | HPV31 |
| Order | Unassigned |
| Virus Family | Papillomaviridae |
| Virus Subfamily | N.A. |
| Genus | Alphapapillomavirus |
| Species | Human papillomavirus 16 |
| Host | Human, monkeys |
| Cell Tropism | Epithelial cells of skin, mucous membranes |
| Associated Disease | Malignant tumours |
| Mode of Transmission | Sexual, indirect and direct contact, auto-inoculation |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/121/papillomaviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Papillomaviridae |
| Paper Title | EVER proteins, key elements of the natural anti-human papillomavirus barrier, are regulated upon T-cell activation |
| Author's Name | Maciej Lazarczyk, Ce cile Dalard, Myriam Hayder, Loc Dupre, Beatrice Pignolet, Slawomir Majewski, Francoise Vuillier, Michel Favre, Roland S. Liblau |
| Journal Name | PLOS One |
| Pubmed ID | 22761942 |
| Abstract | Human papillomaviruses (HPV) cause a variety of mucosal and skin lesions ranging from benign proliferations to invasive carcinomas. The clinical manifestations of infection are determined by host-related factors that define the natural anti-HPV barrier. Key elements of this barrier are the EVER1 and EVER2 proteins, as deficiency in either one of the EVER proteins leads to Epidermodysplasia Verruciformis (EV), a genodermatosis associated with HPV-induced skin carcinoma. Although EVERs have been shown to regulate zinc homeostasis in keratinocytes, their expression and function in other cell types that may participate to the anti-HPV barrier remain to be investigated. In this work, we demonstrate that EVER genes are expressed in different tissues, and most notably in lymphocytes. Interestingly, in contrast to the skin, where EVER2 transcripts are hardly detectable, EVER genes are both abundantly expressed in murine and human T cells. Activation of CD4+ and CD8+ T cells via the TCR triggers a rapid and profound decrease in EVER expression, accompanied by an accumulation of free Zn(2+) ions. Thus, EVER proteins may be involved in the regulation of cellular zinc homeostasis in lymphocytes. Consistent with this hypothesis, we show that the concentration of Zn(2+) ions is elevated in lymphoblastoid cells or primary T cells from EVER2-deficient patients. Interestingly, we also show that Zn(2+) excess blocks T-cell activation and proliferation. Therefore, EVER proteins appear as key components of the activation-dependent regulation of Zn(2+) concentration in T cells. However, the impact of EVER-deficiency in T cells on EV pathogenesis remains to be elucidated. |
| Used Model | BALB/c mice and T cells |
| DOI | 10.1371/journal.pone.0039995 |
