| Gene Name | RAB18 |
| HF Protein Name | Ras-related protein Rab-18 |
| HF Function | Important for viral infection |
| Uniprot ID | Q9NP72 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 22931 |
| Host Factor (HF) Name in Paper | Rab18 |
| Gene synonyms | N.A. |
| Ensemble Gene ID | ENSG00000099246 |
| Ensemble Transcript | ENST00000356940 [Q9NP72-1];ENST00000535776 [Q9NP72-3];ENST00000621805 [Q9NP72-2] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0001654, GO:0003924, GO:0005525, GO:0005622, GO:0005789, GO:0005794, GO:0005829, GO:0005886, GO:0007264, GO:0007420, GO:0015031, GO:0019003, GO:0030667, GO:0034389, GO:0043312, GO:0051170, GO:0070062, GO:0071782, GO:0071786, |
| MINT ID | Q9NP72 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 602207 |
| PANTHER ID | N.A. |
| PDB ID(s) | 1X3S, |
| pfam ID | PF00071, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | BK polyomavirus |
| Virus Short Name | BK |
| Order | Unassigned |
| Virus Family | Polyomaviridae |
| Virus Subfamily | N.A. |
| Genus | Polyomavirus |
| Species | Human polyomavirus 1 |
| Host | Mammals, human |
| Cell Tropism | Respiratory system, kidneys, or brain |
| Associated Disease | Progressive multifocal leukoencephalopathy |
| Mode of Transmission | N.A. |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/129/polyomaviridae |
| Virus Host DB link | N.A. |
| Paper Title | Identification of Rab18 as an Essential Host Factor for BK Polyomavirus Infection Using a Whole-Genome RNA Interference Screen |
| Author's Name | Linbo Zhao, Michael J. Imperiale |
| Journal Name | mSphere (American Society For Microbiology) |
| Pubmed ID | 28815213 |
| Abstract | BK polyomavirus (BKPyV) is a human pathogen first isolated in 1971. BKPyV infection is ubiquitous in the human population, with over 80% of adults worldwide being seropositive for BKPyV. BKPyV infection is usually asymptomatic however, BKPyV reactivation in immunosuppressed transplant patients causes two diseases, polyomavirus-associated nephropathy and hemorrhagic cystitis. To establish a successful infection in host cells, BKPyV must travel in retrograde transport vesicles to reach the nucleus. To make this happen, BKPyV requires the cooperation of host cell proteins. To further identify host factors associated with BKPyV entry and intracellular trafficking, we performed a whole-genome small interfering RNA screen on BKPyV infection of primary human renal proximal tubule epithelial cells. The results revealed the importance of Ras-related protein Rab18 and syntaxin 18 for BKPyV infection. Our subsequent experiments implicated additional factors that interact with this pathway and suggest a more detailed model of the intracellular trafficking process, indicating that BKPyV reaches the endoplasmic reticulum (ER) lumen through a retrograde transport pathway between the late endosome and the ER. |
| Used Model | human renal proximal tubule epithelial cells |
| DOI | 10.1128/mSphereDirect.00291-17 |
