| Virus Name | Human T-lymphotropic virus1 |
| Virus Short Name | HTLV-I |
| Order | Unassigned |
| Virus Family | Retroviridae |
| Virus Subfamily | Orthoretrovirinae |
| Genus | Deltaretrovirus |
| Species | Human T-lymphotropic virus 1 |
| Host | Vertebrates |
| Cell Tropism | Lymphocytes |
| Associated Disease | Adult t-cell leukemia |
| Mode of Transmission | Sexual contact, maternal-neonatal |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/reverse-transcribing-dna-and-rna-viruses-2011/w/rt_viruses/161/retroviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Retroviridae |
| Paper Title | The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV |
| Author's Name | Nicolas Manel, Felix J. Kim, Sandrina Kinet, Naomi Taylor, Marc Sitbon and Jean-Luc Battin |
| Journal Name | Cell |
| Pubmed ID | 14622599 |
| Abstract | The human T cell leukemia virus (HTLV) is associated with leukemia and neurological syndromes. The physiopathological effects of HTLV envelopes are unclear and the identity of the receptor, present on all vertebrate cell lines, has been elusive. We show that the receptor binding domains of both HTLV-1 and -2 envelope glycoproteins inhibit glucose transport by interacting with GLUT-1, the ubiquitous vertebrate glucose transporter. Receptor binding and HTLV envelope-driven infection are selectively inhibited when glucose transport or GLUT-1 expression are blocked by cytochalasin B or siRNAs, respectively. Furthermore, ectopic expression of GLUT-1, but not the related transporter GLUT-3, restores HTLV infection abrogated by either GLUT-1 siRNAs or interfering HTLV envelope glycoproteins. Therefore, GLUT-1 is a receptor for HTLV. Perturbations in glucose metabolism resulting from interactions of HTLV envelope glycoproteins with GLUT-1 are likely to contribute to HTLV-associated disorders. |
| Used Model | T cells |
| DOI | 10.1016/S0092-8674(03)00881-X |
