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Virus Details


VHFID5029

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name NRP1
HF Protein Name Neuropilin-1
HF Function Involves in HTLV-1 Entry
Uniprot ID O14786
Protein Sequence View Fasta Sequence
NCBI Gene ID 8829
Host Factor (HF) Name in Paper NRP1
Gene synonyms NRP VEGF165R
Ensemble Gene ID ENSG00000099250
Ensemble Transcript ENST00000265371 [O14786-1];ENST00000374821 [O14786-3];ENST00000374822 [O14786-2];ENST00000374867 [O14786-1]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0001525, GO:0001569, GO:0001764, GO:0001938, GO:0002040, GO:0002042, GO:0002116, GO:0003148, GO:0005021, GO:0005096, GO:0005615, GO:0005769, GO:0005829, GO:0005883, GO:0005886, GO:0005925, GO:0006930, GO:0007165, GO:0007229, GO:0007267, GO:0007411, GO:0007413, GO:0008201, GO:0009611, GO:0009887, GO:0009986, GO:0010595, GO:0014911, GO:0015026, GO:0016021, GO:0017154, GO:0019838, GO:0019901, GO:0019955, GO:0021612, GO:0021637, GO:0021649, GO:0021675, GO:0021785, GO:0021828, GO:0030424, GO:0030426, GO:0031290, GO:0031410, GO:0031532, GO:0032489, GO:0034446, GO:0035729, GO:0035767, GO:0035924, GO:0036486, GO:0038085, GO:0038189, GO:0038190, GO:0042327, GO:0043005, GO:0043025, GO:0043235, GO:0043524, GO:0043542, GO:0046872, GO:0048008, GO:0048010, GO:0048012, GO:0048842, GO:0048843, GO:0048844, GO:0048846, GO:0050731, GO:0050918, GO:0051491, GO:0051496, GO:0051894, GO:0060301, GO:0060385, GO:0060627, GO:0060666, GO:0060978, GO:0060982, GO:0061299, GO:0061441, GO:0061549, GO:0061551, GO:0,
MINT ID O14786
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 602069
PANTHER ID PTHR44185;PTHR44185:SF1
PDB ID(s) 1KEX, 2QQI, 2QQM, 2QQN, 3I97, 4DEQ, 4RN5, 5C7G, 5IJR, 5IYY, 5J1X, 5JGI, 5JGQ, 5JHK, 5L73,
pfam ID PF00431, PF11980, PF00754, PF00629,
Drug Bank ID DB00039, DB04895,
ChEMBL ID CHEMBL5174
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Human T-lymphotropic virus1
Virus Short Name HTLV-I
Order Unassigned
Virus Family Retroviridae
Virus Subfamily Orthoretrovirinae
Genus Deltaretrovirus
Species Human T-lymphotropic virus 1
Host Vertebrates
Cell Tropism Lymphocytes
Associated Disease Adult t-cell leukemia
Mode of Transmission Sexual contact, maternal-neonatal
VIPR DB link N.A.
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/reverse-transcribing-dna-and-rna-viruses-2011/w/rt_viruses/161/retroviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Retroviridae

Publication Information

Paper Title Neuropilin-1 is involved in human T-cell lymphotropic virus type 1 entry
Author's Name David Ghez, Yves Lepelletier, Sophie Lambert, Jean-Marie Fourneau, Vincent Blot, Sebastien Janvier, Bertrand Arnulf, Peter M. van Endert, Nikolaus Heveker, Claudine Pique, and Olivier Hermine
Journal Name Journal Of Virology
Pubmed ID 16809290
Abstract Human T-cell lymphotropic virus type 1 (HTLV-1) is transmitted through a viral synapse and enters target cells via interaction with the glucose transporter GLUT1. Here, we show that Neuropilin-1 (NRP1), the receptor for semaphorin-3A and VEGF-A165 and a member of the immune synapse, is also a physical and functional partner of HTLV-1 envelope (Env) proteins. HTLV-1 Env and NRP1 complexes are formed in cotransfected cells, and endogenous NRP1 contributes to the binding of HTLV-1 Env to target cells. NRP1 overexpression increases HTLV-1 Env-dependent syncytium formation. Moreover, overexpression of NRP1 increases both HTLV-1 and HTLV-2 Env-dependent infection, whereas down-regulation of endogenous NRP1 has the opposite effect. Finally, overexpressed GLUT1, NRP1, and Env form ternary complexes in transfected cells, and endogenous NRP1 and GLUT1 colocalize in membrane junctions formed between uninfected and HTLV-1-infected T cells. These data show that NRP1 is involved in HTLV-1 and HTLV-2 entry, suggesting that the HTLV receptor has a multicomponent nature.
Used Model Cos cells, HeLa,293T and T cells
DOI 10.1128/JVI.02719-05