| Virus Name | Vesicular stomatitis Indiana virus |
| Virus Short Name | VSV |
| Order | Mononegavirales |
| Virus Family | Rhabdoviridae |
| Virus Subfamily | N.A. |
| Genus | Vesiculovirus |
| Species | Indiana vesiculovirus |
| Host | Human, cattle, horse, swine, sandflies, blackflies |
| Cell Tropism | N.A. |
| Associated Disease | Vesicular diseases, encephalitis |
| Mode of Transmission | Mostely by sandflies |
| VIPR DB link | https://www.viprbrc.org/brc/vipr_allSpecies_search.spg?method=SubmitForm&decorator=rhabdo |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/negative-sense-rna-viruses-2011/w/negrna_viruses/201/rhabdoviridae |
| Virus Host DB link | N.A. |
| Paper Title | LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus |
| Author's Name | Danit Finkelshtein, Ariel Werman, Daniela Novick, Sara Barak, and Menachem Rubinstein |
| Journal Name | PNAS |
| Pubmed ID | 23589850 |
| Abstract | Vesicular stomatitis virus (VSV) exhibits a remarkably robust and pantropic infectivity, mediated by its coat protein, VSV-G. Using this property, recombinant forms of VSV and VSV-G-pseudotyped viral vectors are being developed for gene therapy, vaccination, and viral oncolysis and are extensively used for gene transduction in vivo and in vitro. The broad tropism of VSV suggests that it enters cells through a highly ubiquitous receptor, whose identity has so far remained elusive. Here we show that the LDL receptor (LDLR) serves as the major entry port of VSV and of VSV-G-pseudotyped lentiviral vectors in human and mouse cells, whereas other LDLR family members serve as alternative receptors. The widespread expression of LDLR family members accounts for the pantropism of VSV and for the broad applicability of VSV-G-pseudotyped viral vectors for gene transduction. |
| Used Model | GM701 and CHO cells |
| DOI | 10.1073/pnas.1214441110 |
