| Gene Name | MAT2A |
| HF Protein Name | S-adenosylmethionine synthase isoform type-2 |
| HF Function | Essential for virus replication |
| Uniprot ID | P31153 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 4144 |
| Host Factor (HF) Name in Paper | MAT2A |
| Gene synonyms | AMS2 MATA2 |
| Ensemble Gene ID | ENSG00000168906 |
| Ensemble Transcript | ENST00000306434 [P31153-1];ENST00000409017 [P31153-2] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0004478, GO:0005524, GO:0005829, GO:0006556, GO:0006730, GO:0032259, GO:0034214, GO:0042802, GO:0046872, GO:0048269, GO:0051291, GO:1990830, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 601468 |
| PANTHER ID | PTHR11964 |
| PDB ID(s) | 2P02, 4KTT, 4KTV, 4NDN, 5A19, 5A1G, 5A1I, 5UGH, |
| pfam ID | PF02773, PF02772, PF00438, |
| Drug Bank ID | DB00134, DB00118, |
| ChEMBL ID | CHEMBL3313835 |
| Organism | Homo sapiens (Human) |
| Virus Name | Vesicular stomatitis Indiana virus |
| Virus Short Name | VSV |
| Order | Mononegavirales |
| Virus Family | Rhabdoviridae |
| Virus Subfamily | N.A. |
| Genus | Vesiculovirus |
| Species | Indiana vesiculovirus |
| Host | Human, cattle, horse, swine, sandflies, blackflies |
| Cell Tropism | N.A. |
| Associated Disease | Vesicular diseases, encephalitis |
| Mode of Transmission | Mostely by sandflies |
| VIPR DB link | https://www.viprbrc.org/brc/vipr_allSpecies_search.spg?method=SubmitForm&decorator=rhabdo |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/negative-sense-rna-viruses-2011/w/negrna_viruses/201/rhabdoviridae |
| Virus Host DB link | N.A. |
| Paper Title | A Genome-Wide Small Interfering RNA Screen Identifies Host Factors Required for Vesicular Stomatitis Virus Infection |
| Author's Name | Amy Si-Ying Lee, Rebeca Burdeinick-Kerr, Sean P. J. Whelan |
| Journal Name | Journal Of Virology |
| Pubmed ID | 24829348 |
| Abstract | Viruses are dependent on their host cells for replication and thus have evolved in intimate association with them. The identification of host factors required for viral infection has led to advances in both viral and cellular biology. Vesicular stomatitis virus (VSV), a negative-sense RNA virus, replicates in all eukaryotic cells in culture, suggesting that the host requirements for its replication are ubiquitous. In this study, we performed a genome-wide small interfering RNA screen of human cells in culture and identified multiple cellular genes that influence the entry and replication of VSV. From a list of >300 genes, we selected the most promising candidates to perform further analysis to assign their functions to either the entry or intracellular replication step of infection. We implicate 3 new factors in VSV entry and 20 new factors in viral gene expression. These proteins have diverse cellular roles, including S-adenosylmethionine synthesis, respiration, and host translation machinery, underscoring the intimate relationship between VSV and the host cell. Together, these results provide a curated list of genes required for VSV replication. |
| Used Model | HeLa cells |
| DOI | 10.1128/JVI.00642-14 |
