Hostfactor - VHFIDB

Gene Name	FCGR2B
HF Protein Name	Low affinity immunoglobulin gamma Fc region receptor II-b
HF Function	Essential for virus replication
Uniprot ID	P31994
Protein Sequence	View Fasta Sequence
NCBI Gene ID	2213
Host Factor (HF) Name in Paper	FCGR2B
Gene synonyms	CD32 FCG2 IGFR2
Ensemble Gene ID	ENSG00000072694
Ensemble Transcript	ENST00000236937 [P31994-2];ENST00000358671 [P31994-1];ENST00000367961 [P31994-3]
KEGG ID	Go to KEGG Database
Gene Ontology ID(s)	GO:0001540, GO:0001811, GO:0001814, GO:0002266, GO:0002313, GO:0002316, GO:0002436, GO:0002605, GO:0002622, GO:0002638, GO:0002819, GO:0002865, GO:0002922, GO:0002924, GO:0005886, GO:0005887, GO:0006898, GO:0006911, GO:0006952, GO:0006954, GO:0006955, GO:0007165, GO:0009617, GO:0009897, GO:0010469, GO:0016032, GO:0016064, GO:0019772, GO:0019864, GO:0019886, GO:0021549, GO:0030889, GO:0032693, GO:0038096, GO:0043031, GO:0043197, GO:0043318, GO:0044297, GO:0044877, GO:0045088, GO:0046330, GO:0050710, GO:0050765, GO:0050766, GO:0050776, GO:0050777, GO:0050869, GO:0071219, GO:0090264, GO:1901216, GO:1902564, GO:1902950, GO:1904646, GO:1905898, GO:2001199,
MINT ID	P31994
STRING	Click to see interaction map
GWAS Analysis	Click to see gwas analysis
OMIM ID	152700
PANTHER ID	N.A.
PDB ID(s)	2FCB, 3WJJ,
pfam ID	PF13895,
Drug Bank ID	DB00054, DB00051, DB00092, DB00087, DB00098, DB00074, DB00112, DB00002, DB00111, DB00095, DB00005, DB00056, DB00078, DB00028, DB00075, DB00108, DB00110, DB00073, DB00081, DB00072,
ChEMBL ID	N.A.
Organism	Homo sapiens (Human)

Virus Name	Vesicular stomatitis Indiana virus
Virus Short Name	VSV
Order	Mononegavirales
Virus Family	Rhabdoviridae
Virus Subfamily	N.A.
Genus	Vesiculovirus
Species	Indiana vesiculovirus
Host	Human, cattle, horse, swine, sandflies, blackflies
Cell Tropism	N.A.
Associated Disease	Vesicular diseases, encephalitis
Mode of Transmission	Mostely by sandflies
VIPR DB link	https://www.viprbrc.org/brc/vipr_allSpecies_search.spg?method=SubmitForm&decorator=rhabdo
ICTV DB link	https://talk.ictvonline.org/ictv-reports/ictv_9th_report/negative-sense-rna-viruses-2011/w/negrna_viruses/201/rhabdoviridae
Virus Host DB link	N.A.

Paper Title	A Genome-Wide Small Interfering RNA Screen Identifies Host Factors Required for Vesicular Stomatitis Virus Infection
Author's Name	Amy Si-Ying Lee, Rebeca Burdeinick-Kerr, Sean P. J. Whelan
Journal Name	Journal Of Virology
Pubmed ID	24829348
Abstract	Viruses are dependent on their host cells for replication and thus have evolved in intimate association with them. The identification of host factors required for viral infection has led to advances in both viral and cellular biology. Vesicular stomatitis virus (VSV), a negative-sense RNA virus, replicates in all eukaryotic cells in culture, suggesting that the host requirements for its replication are ubiquitous. In this study, we performed a genome-wide small interfering RNA screen of human cells in culture and identified multiple cellular genes that influence the entry and replication of VSV. From a list of >300 genes, we selected the most promising candidates to perform further analysis to assign their functions to either the entry or intracellular replication step of infection. We implicate 3 new factors in VSV entry and 20 new factors in viral gene expression. These proteins have diverse cellular roles, including S-adenosylmethionine synthesis, respiration, and host translation machinery, underscoring the intimate relationship between VSV and the host cell. Together, these results provide a curated list of genes required for VSV replication.
Used Model	HeLa cells
DOI	10.1128/JVI.00642-14

Virus Details