| Gene Name | Hspa1b |
| HF Protein Name | Heat shock 70 kDa protein 1B |
| HF Function | Essential for virus infection |
| Uniprot ID | P17879 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 15511 |
| Host Factor (HF) Name in Paper | hsp70 |
| Gene synonyms | Hcp70.1 Hsp70-1 Hsp70a1 Hspa1 |
| Ensemble Gene ID | ENSMUSG00000090877 |
| Ensemble Transcript | ENSMUST00000172753 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0002199, GO:0005524, GO:0005622, GO:0005739, GO:0005759, GO:0005813, GO:0007339, GO:0009408, GO:0042026, GO:0043066, GO:0043154, GO:0044297, GO:0090063, GO:1901673, |
| MINT ID | P17879 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | N.A. |
| PANTHER ID | PTHR19375 |
| PDB ID(s) | N.A., |
| pfam ID | PF00012, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Mus musculus (Mouse) |
| Virus Name | Vesicular stomatitis Indiana virus |
| Virus Short Name | VSV |
| Order | Mononegavirales |
| Virus Family | Rhabdoviridae |
| Virus Subfamily | N.A. |
| Genus | Vesiculovirus |
| Species | Indiana vesiculovirus |
| Host | Human, cattle, horse, swine, sandflies, blackflies |
| Cell Tropism | N.A. |
| Associated Disease | Vesicular diseases, encephalitis |
| Mode of Transmission | Mostely by sandflies |
| VIPR DB link | https://www.viprbrc.org/brc/vipr_allSpecies_search.spg?method=SubmitForm&decorator=rhabdo |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/negative-sense-rna-viruses-2011/w/negrna_viruses/201/rhabdoviridae |
| Virus Host DB link | N.A. |
| Paper Title | hsp70-dependent antiviral immunity against cytopathic neuronal infection by vesicular stomatitisvirus |
| Author's Name | Mi Young Kim, Yuanmei Ma, Yu Zhang, Jianrong Li, Yaoling Shu, Michael Oglesbee |
| Journal Name | Journal Of Virology |
| Pubmed ID | 23885078 |
| Abstract | The major inducible 70-kDa heat shock protein (hsp70) protects against measles virus (MeV) neurovirulence in the mouse that is caused by a cell-associated noncytolytic neuronal infection. Protection is type I interferon (IFN) dependent, and we have established a novel axis of antiviral immunity in which hsp70 is released from virus-infected neurons to induce IFN-beta in macrophages. The present work used vesicular stomatitis virus (VSV) to establish the relevance of hsp70-dependent antiviral immunity to fulminant cytopathic neuronal infections. In vitro, hsp70 that was constitutively expressed in mouse neuronal cells caused a modest increase in VSV replication. Infection induced an early extracellular release of hsp70 from viable cells, and the release was progressive, increasing with virus-induced apoptosis and cell lysis. The impact of this VSV-hsp70 interaction on neurovirulence was established in weanling male hsp70 transgenic and nontransgenic mice. Constitutive expression of hsp70 in neurons of transgenic mice enhanced viral clearance from brain and reduced mortality, and it was correlated with enhanced expression of type I IFN mRNA. Nontransgenic mice were also protected against neurovirulence and expressed increased type I IFN mRNA in brain when hsp70 was expressed by a recombinant VSV (rVSV-hsp70), indicating that hsp70 in the virus-infected cell is sufficient for host protection. In vitro data confirmed extracellular release of hsp70 from cells infected with rVSV-hsp70 and also showed that viral replication is not enhanced when hsp70 is expressed in this manner, suggesting that hsp70-mediated protection in vivo is not dependent on stimulatory effects of hsp70 on virus gene expression. |
| Used Model | C57BL/6 mice |
| DOI | 10.1128/JVI.00872-13 |
