| Gene Name | CD209 |
| HF Protein Name | CD209 antigen |
| HF Function | Essential host factor for JEV early infection |
| Uniprot ID | Q9NNX6 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 30835 |
| Host Factor (HF) Name in Paper | DC-SIGN |
| Gene synonyms | CLEC4L |
| Ensemble Gene ID | ENSG00000090659 |
| Ensemble Transcript | ENST00000204801 [Q9NNX6-7];ENST00000315591 [Q9NNX6-6];ENST00000315599 [Q9NNX6-1];ENST00000354397 [Q9NNX6-2];ENST00000394161 [Q9NNX6-4];ENST00000601256 [Q9NNX6-12];ENST00000601951 [Q9NNX6-10];ENST00000602261 [Q9NNX6-3] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0001618, GO:0002223, GO:0002250, GO:0005537, GO:0005737, GO:0005886, GO:0006897, GO:0007157, GO:0007159, GO:0009897, GO:0009986, GO:0009988, GO:0016020, GO:0016021, GO:0019048, GO:0019062, GO:0019079, GO:0019882, GO:0030246, GO:0035556, GO:0042102, GO:0042129, GO:0042605, GO:0043657, GO:0045087, GO:0046790, GO:0046872, GO:0046968, GO:0070062, GO:0075733, GO:0097323, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 604672 |
| PANTHER ID | N.A. |
| PDB ID(s) | 1K9I, 1SL4, 1SL5, 2B6B, 2IT5, 2IT6, 2XR5, 2XR6, |
| pfam ID | PF00059, |
| Drug Bank ID | N.A., |
| ChEMBL ID | CHEMBL1795114 |
| Organism | Homo sapiens (Human) |
| Virus Name | Japanese encephalitis virus |
| Virus Short Name | JEV |
| Order | Unassigned |
| Virus Family | Flaviviridae |
| Virus Subfamily | N.A. |
| Genus | Flavivirus |
| Species | Japanese encephalitis virus |
| Host | Human, mammals, mosquitoes and ticks |
| Cell Tropism | N.A. |
| Associated Disease | Hemorrhagic fever, encephalitis |
| Mode of Transmission | Arthropod bite, mainly mosquitoes |
| VIPR DB link | http://www.viprbrc.org/brc/home.spg?decorator=flavi |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/flaviviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Flaviviridae |
| Paper Title | DC-SIGN as an attachment factor mediates Japanese encephalitis virus infection of human dendritic cells via interaction with a single high-mannose residue of viral E glycoprotein |
| Author's Name | Ping Wang, Kai Hu, Sukun Luo, Mudan Zhang, Xu Deng, Chang Li, Wei Jin, Bodan Hu, Siyi He, Mei Li, Tao Du, Gengfu Xiao, Bo Zhang, Yalan Liu, Qinxue Hu |
| Journal Name | Virology |
| Pubmed ID | 26629951 |
| Abstract | The skin-resident dendritic cells (DCs) are thought to be the first defender to encounter incoming viruses and likely play a role in Japanese encephalitis virus (JEV) early infection. In the current study, following the demonstration of JEV productive infection in DCs, we revealed that the interaction between JEV envelope glycoprotein (E glycoprotein) and DC-SIGN was important for such infection as evidenced by antibody neutralization and siRNA knockdown experiments. Moreover, the high-mannose N-linked glycan at N154 of Eglycoprotein was shown to be crucial for JEV binding to DC-SIGN and subsequent internalization, while mutation of DC-SIGNinternalization motif did not affect JEV uptake and internalization. These data together suggest that DC-SIGN functions as an attachment factor rather than an entry receptor for JEV. Our findings highlight the potential significance of DC-SIGN in JEV early infection, providing a basis for further understanding how JEV exploits DC-SIGN to gain access to dendritic cells. |
| Used Model | CHO, BHK and HEK-293T cells |
| DOI | 10.1016/j.virol.2015.11.006 |
