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Virus Details


VHFID6560

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name CAV1
HF Protein Name Caveolin-1
HF Function Virus entry receptor
Uniprot ID Q03135
Protein Sequence View Fasta Sequence
NCBI Gene ID 857
Host Factor (HF) Name in Paper CAV1
Gene synonyms CAV
Ensemble Gene ID ENSG00000105974
Ensemble Transcript ENST00000341049 [Q03135-1];ENST00000393467 [Q03135-2];ENST00000393468 [Q03135-2];ENST00000405348 [Q03135-2];ENST00000614113 [Q03135-2]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000122, GO:0000139, GO:0000188, GO:0001525, GO:0001570, GO:0001666, GO:0001937, GO:0001960, GO:0002080, GO:0002931, GO:0003057, GO:0005102, GO:0005113, GO:0005198, GO:0005622, GO:0005768, GO:0005783, GO:0005789, GO:0005811, GO:0005886, GO:0005887, GO:0005901, GO:0005925, GO:0005929, GO:0005938, GO:0006641, GO:0006816, GO:0006874, GO:0006940, GO:0007519, GO:0007595, GO:0008104, GO:0009267, GO:0009617, GO:0010524, GO:0010608, GO:0010628, GO:0015485, GO:0016020, GO:0016050, GO:0016323, GO:0016324, GO:0016504, GO:0019065, GO:0019217, GO:0019899, GO:0019901, GO:0019915, GO:0030193, GO:0030301, GO:0030512, GO:0030514, GO:0030666, GO:0030674, GO:0030857, GO:0030879, GO:0031295, GO:0031397, GO:0031398, GO:0031410, GO:0031623, GO:0031901, GO:0032091, GO:0032092, GO:0032507, GO:0032570, GO:0032947, GO:0032991, GO:0033137, GO:0033138, GO:0033484, GO:0034141, GO:0042310, GO:0042532, GO:0042632, GO:0042802, GO:0043085, GO:0043409, GO:0043627, GO:0044325, GO:0044860, GO:0045019, GO:0045121, GO:0,
MINT ID Q03135
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 601047
PANTHER ID PTHR10844;PTHR10844:SF18
PDB ID(s) N.A.,
pfam ID PF01146,
Drug Bank ID N.A.,
ChEMBL ID CHEMBL3808270
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Japanese encephalitis virus
Virus Short Name JEV
Order Unassigned
Virus Family Flaviviridae
Virus Subfamily N.A.
Genus Flavivirus
Species Japanese encephalitis virus
Host Human, mammals, mosquitoes and ticks
Cell Tropism N.A.
Associated Disease Hemorrhagic fever, encephalitis
Mode of Transmission Arthropod bite, mainly mosquitoes
VIPR DB link http://www.viprbrc.org/brc/home.spg?decorator=flavi
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/flaviviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Flaviviridae

Publication Information

Paper Title Caveolin-1-mediated Japanese encephalitis virus entry requires a two-step regulation of actinreorganization
Author's Name Qingqiang Xu, Mingmei Cao, Hongyuan Song, Shenglin Chen, Xijing Qian, Ping Zhao, Hao Ren, Hailin Tang, Yan Wang, Youheng Wei, Yongzhe Zhu & Zhongtian Qi
Journal Name future MICROBIOLOGY
Pubmed ID 26986451
Abstract Aim: To investigate the detailed mechanism of Japanese encephalitis virus (JEV) cell entry. Materials & methods: Utilize a siRNA library targeting cellular membrane trafficking genes to identify key molecules that mediate JEV entry into human neuronal cells. Results: JEV enters human neuronal cells by caveolin‐1‐mediated endocytosis, which depends on a two-step regulation of actin cytoskeleton remodeling triggered by RhoA and Rac1: RhoA activation promoted the phosphorylation of caveolin‐1, and then Rac1 activation facilitated caveolin-associated viral internalization. Specifically, virus attachment activates the EGFR–PI3K signaling pathway, thereby leading to RhoA activation. Conclusion: This work provides a detailed picture of the entry route and intricate cellular events following the entry of JEV into human neuronal cells, and promotes a better understanding of JEV entry.
Used Model SK-N-SH, BHK-22 and HEK-293T cells
DOI 10.2217/fmb-2016-0002