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Virus Details


VHFID6562

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name ITGB3
HF Protein Name Integrin beta-3
HF Function Promotes infection by Japanese Encephalitis Virus
Uniprot ID P05106
Protein Sequence View Fasta Sequence
NCBI Gene ID 3690
Host Factor (HF) Name in Paper ITGB3
Gene synonyms GP3A
Ensemble Gene ID ENSG00000259207
Ensemble Transcript ENST00000559488 [P05106-1]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0001618, GO:0001934, GO:0001938, GO:0001968, GO:0002020, GO:0002576, GO:0003756, GO:0005161, GO:0005178, GO:0005634, GO:0005886, GO:0005887, GO:0005925, GO:0007044, GO:0007155, GO:0007160, GO:0007229, GO:0007596, GO:0008305, GO:0009986, GO:0010595, GO:0010745, GO:0010888, GO:0014909, GO:0015026, GO:0019899, GO:0030168, GO:0030198, GO:0030949, GO:0031092, GO:0031258, GO:0031527, GO:0031528, GO:0031589, GO:0032147, GO:0032369, GO:0032587, GO:0033627, GO:0034113, GO:0034446, GO:0034683, GO:0035295, GO:0035866, GO:0035867, GO:0035868, GO:0038027, GO:0042060, GO:0042470, GO:0042802, GO:0043184, GO:0043235, GO:0043277, GO:0045124, GO:0045715, GO:0046718, GO:0048010, GO:0048333, GO:0050731, GO:0050748, GO:0050839, GO:0050840, GO:0050900, GO:0050919, GO:0060055, GO:0070062, GO:0070527, GO:0071062,
MINT ID P05106
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 173470
PANTHER ID PTHR10082;PTHR10082:SF25
PDB ID(s) 1JV2, 1KUP, 1KUZ, 1L5G, 1M1X, 1M8O, 1MIZ, 1MK7, 1MK9, 1RN0, 1S4X, 1TYE, 1U8C, 2INI, 2K9J, 2KNC, 2KV9, 2L1C, 2L91, 2LJD, 2LJE, 2LJF, 2MTP, 2N9Y, 2Q6W, 2RMZ, 2RN0, 2VC2, 2VDK, 2VDL, 2VDM, 2VDN, 2VDO, 2VDP, 2VDQ, 2VDR, 3FCS, 3FCU, 3IJE, 3NID, 3NIF, 3NIG, 3T3M, 3T3P, 3ZDX, 3ZDY, 3ZDZ, 3ZE0, 3ZE1, 3ZE2, 4CAK, 4G1E, 4G1M, 4MMX, 4MMY, 4MMZ, 4O02, 4Z7N, 4Z7O, 4Z7Q, 5HDB, 6AVQ, 6AVR, 6AVU,
pfam ID PF07974, PF08725, PF07965, PF00362, PF17205,
Drug Bank ID DB00054, DB00098, DB00063, DB04863, DB05787, DB00775,
ChEMBL ID CHEMBL2111461
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Japanese encephalitis virus
Virus Short Name JEV
Order Unassigned
Virus Family Flaviviridae
Virus Subfamily N.A.
Genus Flavivirus
Species Japanese encephalitis virus
Host Human, mammals, mosquitoes and ticks
Cell Tropism N.A.
Associated Disease Hemorrhagic fever, encephalitis
Mode of Transmission Arthropod bite, mainly mosquitoes
VIPR DB link http://www.viprbrc.org/brc/home.spg?decorator=flavi
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/flaviviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Flaviviridae

Publication Information

Paper Title Integrin alphavbeta3 promotes infection by Japanese encephalitis virus
Author's Name Wenchun Fan, Ping Qian, Dandan Wang, Xianwei Zhi, Yanming Wei, Huanchun Chen, Xiangmin Li
Journal Name Research in Veterinary Science
Pubmed ID 28043010
Abstract Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that is one of the major causes of viral encephalitis diseases worldwide. The JEV envelope protein facilitates viral entry, and its domain III contains an Arg-Gly-Asp (RGD) motif, that may modulate JEV entrythrough the RGD-binding integrin. In this study, the roles of integrin alphav and beta3 on the infection of JEV were evaluated. Reduced expression of integrin alphav/beta3 by special shRNA confers 2 to 4-fold inhibition of JEV replication in BHK-21 cells. Meanwhile, antibodies specific for integrin alphav/beta3 displayed ~58% and ~33% inhibition of JEV infectivity and RGD-specific peptides produced ~36% of inhibition. Expression of E protein and JEV RNA loads were clearly increased in CHO cells transfected with cDNA encoding human integrin beta3. Moreover, integrin alphav mediates JEV infection in viral binding stage of life cycle. Therefore, our study suggested that integrin alphav and beta3 serve as a host factor associated with JEV entry into the target cells.
Used Model BHK-21 and CHO cells
DOI 10.1016/j.rvsc.2016.12.007