| Gene Name | NFIA |
| HF Protein Name | Nuclear factor 1 A-type |
| HF Function | Negatively regulates JC virus multiplication |
| Uniprot ID | Q12857 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 4774 |
| Host Factor (HF) Name in Paper | NF-1A |
| Gene synonyms | KIAA1439 |
| Ensemble Gene ID | ENSG00000162599 |
| Ensemble Transcript | ENST00000371187 [Q12857-2];ENST00000371189 [Q12857-4];ENST00000403491 [Q12857-1];ENST00000407417 [Q12857-3] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000122, GO:0000978, GO:0000981, GO:0001077, GO:0003682, GO:0003700, GO:0005634, GO:0005654, GO:0006260, GO:0006355, GO:0008134, GO:0019079, GO:0030054, GO:0045944, GO:0060074, GO:0072189, |
| MINT ID | Q12857 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 600727 |
| PANTHER ID | PTHR11492 |
| PDB ID(s) | N.A., |
| pfam ID | PF00859, PF03165, PF10524, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | JC Virus |
| Virus Short Name | JC |
| Order | Unassigned |
| Virus Family | Polyomaviridae |
| Virus Subfamily | N.A. |
| Genus | Polyomavirus |
| Species | JC polyomavirus |
| Host | Mammals, human |
| Cell Tropism | Respiratory system, kidneys, or brain |
| Associated Disease | Progressive multifocal leukoencephalopathy |
| Mode of Transmission | N.A. |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/129/polyomaviridae |
| Virus Host DB link | N.A. |
| Paper Title | DNA-binding transcription factor NF-1A negatively regulates JC virus multiplication |
| Author's Name | Veerasamy Ravichandran and Eugene O. Major |
| Journal Name | Journal Of General Virology |
| Pubmed ID | 18474555 |
| Abstract | JC virus (JCV) DNA replication occurs in the nuclei of infected cells. The level of JCV genome expression depends on nucleotide sequences in the viral regulatory region and their interaction with host-cell nuclear transcription factors. Our previous studies showed a higher level of NF-1X in JCV-permissive cells compared with the other members of the NF-1 family, NF-1A, B and C, which suggests that NF-1X plays a positive role in JCV multiplication. It remained unclear whether a reduction in the level of NF-1A, which is expressed abundantly in JCV-non-permissive cell types, leads to an increase in JCV multiplication. In this study, we show that downregulation of NF-1A expression in JCV-non-susceptible progenitor and HeLa cells results in a reversion to susceptibility for JCV multiplication. These data demonstrate that a higher level of NF-1A protein in JCV-non-permissive cell types, compared with the level of NF-1X, may be acting as a negative regulator at the JCV promoter to control JCV multiplication. |
| Used Model | HeLa cells |
| DOI | 10.1099/vir.0.2008/000059-0 |
