| Gene Name | IRF7 |
| HF Protein Name | Interferon regulatory factor 7 |
| HF Function | Antiviral protein |
| Uniprot ID | Q92985 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 3665 |
| Host Factor (HF) Name in Paper | IRF7 |
| Gene synonyms | N.A. |
| Ensemble Gene ID | ENSG00000185507 |
| Ensemble Transcript | ENST00000330243 [Q92985-4];ENST00000348655 [Q92985-2];ENST00000397566 [Q92985-4];ENST00000397574 [Q92985-1];ENST00000469048 [Q92985-3];ENST00000533182 [Q92985-3];ENST00000612534 [Q92985-4];ENST00000621391 [Q92985-1];ENST00000632827 [Q92985-4];ENST00000633274 [Q92985-3];ENST00000633943 [Q92985-2];ENST00000634105 [Q92985-3] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000122, GO:0000979, GO:0000981, GO:0000982, GO:0002819, GO:0003677, GO:0005634, GO:0005654, GO:0005737, GO:0005829, GO:0006366, GO:0006974, GO:0009615, GO:0010008, GO:0016064, GO:0019043, GO:0032479, GO:0032481, GO:0032607, GO:0032608, GO:0032727, GO:0032728, GO:0034124, GO:0034127, GO:0035666, GO:0039530, GO:0045087, GO:0045351, GO:0045655, GO:0045893, GO:0045944, GO:0050776, GO:0051607, GO:0060333, GO:0060337, GO:0060340, GO:2000110, |
| MINT ID | Q92985 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 605047 |
| PANTHER ID | PTHR11949 |
| PDB ID(s) | 2O61, |
| pfam ID | PF00605, PF10401, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Lymphocytic choriomeningitis virus |
| Virus Short Name | LCMV |
| Order | Unassigned |
| Virus Family | Arenaviridae |
| Virus Subfamily | N.A. |
| Genus | Mammarenavirus |
| Species | Lymphocytic choriomeningitis virus |
| Host | Rodents and human |
| Cell Tropism | Macrophages |
| Associated Disease | Encephalitis |
| Mode of Transmission | Zoonosis, fomite |
| VIPR DB link | https://www.viprbrc.org/brc/vipr_allSpecies_search.spg?method=SubmitForm&decorator=arena |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/negative-sense-rna-viruses-2011/w/negrna_viruses/203/arenaviridae |
| Virus Host DB link | N.A. |
| Paper Title | IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus |
| Author's Name | Wen Li, Markus J. Hofer, So Ri Jung, Sue-Ling Lim, Iain L. Campbell |
| Journal Name | Journal Of Virology |
| Pubmed ID | 22065774 |
| Abstract | Negative-strand (NS) RNA viruses comprise many pathogens that cause serious diseases in humans and animals. Despite their clinical importance, little is known about the host factors required for their infection. Using vesicular stomatitis virus (VSV), a prototypic NS RNA virus in the family Rhabdoviridae, we conducted a human genome-wide siRNA screen and identified 72 host genes required for viral infection. Many of these identified genes were also required for infection by two other NS RNA viruses, the lymphocytic choriomeningitis virus of the Arenaviridae family and human parainfluenza virus type 3 of the Paramyxoviridae family. Genes affecting different stages of VSV infection, such as entry/uncoating, gene expression, and assembly/release, were identified. Depletion of the proteins of the coatomer complex I or its upstream effectors ARF1 or GBF1 led to detection of reduced levels of VSV RNA. Coatomer complex I was also required for infection of lymphocytic choriomeningitis virus and human parainfluenza virus type 3. These results highlight the evolutionarily conserved requirements for gene expression of diverse families of NS RNA viruses and demonstrate the involvement of host cell secretory pathway in the process. |
| Used Model | STAT1 KO mice, STAT2 KO mice, IRF7 KO and IFNAR KO mice |
| DOI | 10.1128/JVI.03117-13 |
