| Gene Name | CD46 |
| HF Protein Name | Membrane cofactor protein |
| HF Function | Essential for MV entry |
| Uniprot ID | P15529 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 4179 |
| Host Factor (HF) Name in Paper | CD46 |
| Gene synonyms | MCP MIC10 |
| Ensemble Gene ID | ENSG00000117335 |
| Ensemble Transcript | ENST00000322875 [P15529-2];ENST00000322918 [P15529-9];ENST00000354848 [P15529-3];ENST00000357714 [P15529-4];ENST00000358170 [P15529-1];ENST00000360212 [P15529-7];ENST00000367041 [P15529-12];ENST00000367042 [P15529-11];ENST00000367047 [P15529-16];ENST00000480003 [P15529-6] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0001618, GO:0002079, GO:0002250, GO:0002456, GO:0004872, GO:0005886, GO:0005887, GO:0005925, GO:0006958, GO:0007338, GO:0008593, GO:0009986, GO:0010628, GO:0010629, GO:0030449, GO:0032613, GO:0032733, GO:0035581, GO:0042102, GO:0043382, GO:0045087, GO:0045296, GO:0045591, GO:0070062, GO:0071636, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 120920 |
| PANTHER ID | N.A. |
| PDB ID(s) | 1CKL, 1HR4, 2O39, 3INB, 3L89, 3O8E, 5FO8, |
| pfam ID | PF00084, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Measles Virus |
| Virus Short Name | MeV |
| Order | Mononegavirales |
| Virus Family | Paramyxoviridae |
| Virus Subfamily | N.A. |
| Genus | Morbilivirus |
| Species | Measles morbillivirus |
| Host | Human, dog, cattle |
| Cell Tropism | N.A. |
| Associated Disease | Fever, rash |
| Mode of Transmission | Respiratory |
| VIPR DB link | http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=paramyxo |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/negative-sense-rna-viruses-2011/w/negrna_viruses/199/paramyxoviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Paramyxoviridae |
| Paper Title | Role of CD46 in measles virus infection in CD46 transgenic mice |
| Author's Name | Merete Blixenkrone-Moller,Arlette Bernard, Anne Bencsik, Nathalie Sixt, Lisa E. Diamond, John S. Logan and T. Fabian Wild |
| Journal Name | Virology |
| Pubmed ID | 9791016 |
| Abstract | The susceptibility of CD46 (human membrane cofactor protein) transgenic mice to measles virus (MV) infection was investigated. Cell cultures (lung and kidney) established from transgenic and control mice showed that although both could be infected only those from the CD46+ mice gave fusion. A complete round of replication with the release of infectious virus was detected exclusively in the transgenic cell cultures whose permissiveness to MV was markedly less than that of Vero cells. The ability of MV to replicate in vivo in mice was studied using both vaccine and laboratory-adapted wild-type strains of virus. After intraperitoneal and intranasal inoculations of transgenic mice, virus replication could not be detected. In contrast intracerebral inoculation induced infection in both transgenic and nontransgenic mice. Our results from in vitro infection studies support the hypothesis that CD46 is a major host cell factor involved in the MV-induced fusion process and MV entry. The studies further indicate that MV tropism is not governed solely by the expression of the CD46 gene and that the high efficiency of the replicative cycles characteristic of fully permissive host cells requires additional factors, which are lacking in both transgenic and nontransgenic mice. |
| Used Model | CD46-transgenic mice |
| DOI | 10.1006/viro.1998.9301 |
