| Gene Name | Mgat5 |
| HF Protein Name | Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A |
| HF Function | Involves in MVMp infection |
| Uniprot ID | Q8R4G6 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 107895 |
| Host Factor (HF) Name in Paper | Mgat5 |
| Gene synonyms | N.A. |
| Ensemble Gene ID | ENSMUSG00000036155 |
| Ensemble Transcript | ENSMUST00000038361;ENSMUST00000171405 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000139, GO:0005794, GO:0006487, GO:0008375, GO:0016021, GO:0016757, GO:0030144, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | N.A. |
| PANTHER ID | PTHR15075 |
| PDB ID(s) | N.A., |
| pfam ID | PF15027, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Mus musculus (Mouse) |
| Virus Name | Mice minute virus |
| Virus Short Name | MMV |
| Order | Unassigned |
| Virus Family | Parvoviridae |
| Virus Subfamily | Parvovirinae |
| Genus | Protoparvovirus |
| Species | Mice minute virus |
| Host | Vertebrates |
| Cell Tropism | Mice minute virus p & i: fibroblasts & lymphocytes |
| Associated Disease | Gastrointestinal tract damage |
| Mode of Transmission | Respiratory, oral droplets of fecal oral-route |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/ssdna-viruses-2011/w/ssdna_viruses/151/parvoviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Parvoviridae |
| Paper Title | Galectin-3 plays a role in minute virus of mice infection |
| Author's Name | Pierre O. Garcin , Ivan R. Nabi, Nelly Pante |
| Journal Name | Virology |
| Pubmed ID | 25768892 |
| Abstract | Galectin-3 has previously been found to be required by the parvovirus minute virus of mice prototype strain (MVMp) for infection of mouse fibroblast cells. Since MVMp is an oncotropic virus, and galectin-3 is a multifunctional protein implicated in cancer metastasis, we hypothesized that galectin-3 and Mgat5, the Golgi enzyme that synthesizes high-affinity glycan ligands of galectin-3, might play a role in MVMp infection. Using siRNA-mediated knockdown of galectin-3 in mouse cells transformed with polyomavirus middle T antigen and Mgat5/ mouse mammary tumor cells, we found that galectin-3 and Mgat5 are both necessary for efficient MVMp cell entry and infection, but not for cell binding. Moreover, we found that human cancer cells expressing higher levels of galectin-3 were more efficiently infected with MVMp than cell lines expressing lower galectin-3 levels. We conclude that galectin-3 and Mgat5 are involved in MVMp infection, and propose that galectin-3 is a determinant of MVMp oncotropism. |
| Used Model | PyMT cells |
| DOI | 10.1016/j.virol.2015.02.019 |
