| Virus Name | Mouse mammary tumor virus |
| Virus Short Name | MMTV |
| Order | Unassigned |
| Virus Family | Retroviridae |
| Virus Subfamily | Orthoretrovirinae |
| Genus | Gammaretrovirus |
| Species | Mouse mammary tumor virus |
| Host | Vertebrates |
| Cell Tropism | T and B cells located in Peyer?s patches of the gastrointestinal tracts of neonatally infected pups |
| Associated Disease | N.A. |
| Mode of Transmission | N.A. |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/reverse-transcribing-dna-and-rna-viruses-2011/w/rt_viruses/161/retroviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Retroviridae |
| Paper Title | Identification of the segments of the mouse transferrin receptor 1 required for mouse mammary tumor virus infection |
| Author's Name | Enxiu Wang, Lorraine Albritton, and Susan R. Ross |
| Journal Name | The Journal Of Biological Chemistry |
| Pubmed ID | 16481319 |
| Abstract | Most enveloped viruses enter cells through binding of virion surface envelope proteins to receptors found on the plasma membrane of the cell. The beta retrovirus mouse mammary tumor virus (MMTV) uses transferrin receptor 1 (TfR1) to enter cells in a pH-dependent mechanism, probably co-trafficking with TfR1 to an acidic compartment where virus entry occurs. We have shown here that, although mouse and rat TfR1 function as entry receptors, cat, dog, hamster, or human TfR1s do not support MMTV infection. We also demonstrated that MMTV entry is independent of transferrin, iron, and the TfR1 cofactor hereditary hematochromatosis HFE protein. Using chimeric mouse/human hybrid TfR1 constructs, we determined the site of interaction with MMTV and found that it maps to two segments physically disparate from the TfR and HFE binding sites. Thus, MMTV has apparently evolved to enter cells independently of the iron status of the host. |
| Used Model | 293T, XC and Tvb.2 cells |
| DOI | 10.1074/jbc.M511572200 |
