| Gene Name | Tnfrsf13c |
| HF Protein Name | Tumor necrosis factor receptor superfamily member 13C |
| HF Function | Receptor for mhv68 |
| Uniprot ID | Q9D8D0 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 72049 |
| Host Factor (HF) Name in Paper | BAFFR |
| Gene synonyms | Baffr Bcmd Br3 |
| Ensemble Gene ID | ENSMUSG00000068105 |
| Ensemble Transcript | ENSMUST00000089161 [Q9D8D0-1] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0001782, GO:0002250, GO:0002636, GO:0009897, GO:0016021, GO:0030890, GO:0031295, GO:0031296, GO:0042102, GO:0045078, GO:0050776, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | N.A. |
| PANTHER ID | PTHR20437:SF2 |
| PDB ID(s) | N.A., |
| pfam ID | PF09256, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Mus musculus (Mouse) |
| Virus Name | Murine gammaherpesvirus 68 |
| Virus Short Name | MHV-68 |
| Order | Herpesvirales |
| Virus Family | Herpesviridae |
| Virus Subfamily | Gammaherpesvirinae |
| Genus | Rhadinovirus |
| Species | Murid herpesvirus 68 |
| Host | Murine,mammals |
| Cell Tropism | B lymphocytes |
| Associated Disease | Mononucleosis, associated with environemental diseases: burkitt?s lymphoma nasopharyngeal carcinoma (npc) |
| Mode of Transmission | Contact, saliva |
| VIPR DB link | http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae |
| Paper Title | BAFF receptor deficiency limits gammaherpesvirus infection |
| Author's Name | Bruno Frederico, Janet S. May, Stacey Efstathiou, Philip G. Stevenson |
| Journal Name | Journal Of Virology |
| Pubmed ID | 24501409 |
| Abstract | Lymphocyte colonization by gammaherpesviruses (gammaHVs) is an important target for cancer prevention. However, how it works is not clear. Epstein-Barr virus drives autonomous B cell proliferation in vitro but in vivo may more subtly exploit the proliferative pathways provided by lymphoid germinal centers (GCs). Murid herpesvirus 4 (MuHV-4), which realistically infects inbred mice, provides a useful tool with which to understand further how a gammaHV colonizes B cells in vivo. Not all gammaHVs necessarily behave the same, but common events can with MuHV-4 be assigned an importance for host colonization and so a potential as therapeutic targets. MuHV-4-driven B cell proliferation depends quantitatively on CD4(+) T cell help. Here we show that it also depends on T cell-independent survival signals provided by the B cell-activating factor (BAFF) receptor (BAFF-R). B cells could be infected in BAFF-R(-/-) mice, but virus loads remained low. This corresponded to a BAFF-R-dependent defect in GC colonization. The close parallels between normal, antigen-driven B cell responses and virus-infected B cell proliferation argue that in vivo, gammaHVs mostly induce infected B cells into normal GC reactions rather than generating large numbers of autonomously proliferating blasts. |
| Used Model | C57BL/6J and BAFF-R-/- mice |
| DOI | 10.1128/JVI.03497-13 |
