Download Help

Virus Details


VHFID6765

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name PSMC5
HF Protein Name 26S protease regulatory subunit 8
HF Function Activates interferon-beta after virus infection
Uniprot ID P62195
Protein Sequence View Fasta Sequence
NCBI Gene ID 5705
Host Factor (HF) Name in Paper PSMC5
Gene synonyms SUG1
Ensemble Gene ID ENSG00000087191
Ensemble Transcript ENST00000310144 [P62195-1];ENST00000375812 [P62195-2];ENST00000580864 [P62195-2];ENST00000581882 [P62195-2]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000165, GO:0000209, GO:0000502, GO:0002223, GO:0002479, GO:0005524, GO:0005634, GO:0005654, GO:0005737, GO:0005829, GO:0006357, GO:0006521, GO:0008134, GO:0008540, GO:0010972, GO:0016020, GO:0016234, GO:0016579, GO:0016887, GO:0017025, GO:0022624, GO:0030433, GO:0031145, GO:0031146, GO:0031410, GO:0031531, GO:0031595, GO:0031597, GO:0033209, GO:0036402, GO:0038061, GO:0038095, GO:0043069, GO:0043161, GO:0043488, GO:0043687, GO:0045892, GO:0045893, GO:0045899, GO:0050804, GO:0050852, GO:0051436, GO:0051437, GO:0055085, GO:0060071, GO:0061418, GO:0070062, GO:0070498, GO:0072562, GO:0090090, GO:0090261, GO:0090263, GO:0098794, GO:1902036,
MINT ID P62195
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 601681
PANTHER ID PTHR23073:SF12
PDB ID(s) 2KRK, 3KW6, 5GJQ, 5GJR, 5L4G, 5LN3, 5M32, 5T0C, 5T0G, 5T0H, 5T0I, 5T0J, 5VGZ, 5VHF, 5VHH, 5VHI, 5VHJ, 5VHM, 5VHN, 5VHO, 5VHP, 5VHQ, 5VHR, 5VHS,
pfam ID PF00004,
Drug Bank ID N.A.,
ChEMBL ID CHEMBL2364701
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Sendai virus
Virus Short Name SeV
Order Mononegavirales
Virus Family Paramyxoviridae
Virus Subfamily N.A.
Genus Respirovirus
Species Murine respirovirus
Host Mammals
Cell Tropism N.A.
Associated Disease Acute febrile respiratory tract infection
Mode of Transmission Respiratory
VIPR DB link http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=paramyxo
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/negative-sense-rna-viruses-2011/w/negrna_viruses/199/paramyxoviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Paramyxoviridae

Publication Information

Paper Title Genome-wide RNAi screen reveals a new role of a WNT/ CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses
Author's Name Martin Baril, Salwa Es-Saad, Laurent Chatel-Chaix, Karin Fink, Tram Pham, Vale rie-Ann Raymond, Karine Audette, Anne-Sophie Guenier, Jean Duchaine, Marc Servant, Marc Bilodeau, E ric Cohen, Nathalie Grandvaux, Daniel Lamarre
Journal Name PLOS Pathogens
Pubmed ID 23785285
Abstract To identify new regulators of antiviral innate immunity, we completed the first genome-wide gene silencing screen assessing the transcriptional response at the interferon-beta (IFNB1) promoter following Sendai virus (SeV) infection. We now report a novel link between WNT signaling pathway and the modulation of retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-dependent innate immune responses. Here we show that secretion of WNT2B and WNT9B and stabilization of beta-catenin (CTNNB1) upon virus infection negatively regulate expression of representative inducible genes IFNB1, IFIT1 and TNF in a CTNNB1-dependent effector mechanism. The antiviral response is drastically reduced by glycogen synthase kinase 3 (GSK3) inhibitors but restored in CTNNB1 knockdown cells. The findings confirm a novel regulation of antiviral innate immunity by a canonical-like WNT/CTNNB1 signaling pathway. The study identifies novel avenues for broad-spectrum antiviral targets and preventing immune-mediated diseases upon viral infection.
Used Model HEK 293T and A549 cells
DOI 10.1371/journal.ppat.1003416