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Virus Details


VHFID6772

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name RAN
HF Protein Name GTP-binding nuclear protein Ran
HF Function Activates interferon-beta after virus infection
Uniprot ID P62826
Protein Sequence View Fasta Sequence
NCBI Gene ID 5901
Host Factor (HF) Name in Paper RAN
Gene synonyms ARA24
Ensemble Gene ID ENSG00000132341
Ensemble Transcript ENST00000392369;ENST00000543796
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000055, GO:0000056, GO:0000060, GO:0000070, GO:0000278, GO:0000287, GO:0003682, GO:0003713, GO:0003723, GO:0003924, GO:0005525, GO:0005634, GO:0005635, GO:0005643, GO:0005654, GO:0005730, GO:0005737, GO:0005814, GO:0005829, GO:0006259, GO:0006409, GO:0006606, GO:0006611, GO:0007052, GO:0010586, GO:0016020, GO:0016032, GO:0019003, GO:0030496, GO:0030521, GO:0032092, GO:0032991, GO:0035281, GO:0042470, GO:0042565, GO:0043657, GO:0045296, GO:0045540, GO:0045893, GO:0046039, GO:0046982, GO:0050681, GO:0051301, GO:0055037, GO:0060964, GO:0061015, GO:0070062, GO:0075733, GO:1902570,
MINT ID P62826
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 601179
PANTHER ID PTHR24071
PDB ID(s) 1I2M, 1IBR, 1K5D, 1K5G, 1QBK, 1RRP, 2MMC, 2MMG, 2N1B, 3CH5, 3EA5, 3GJ0, 3GJ3, 3GJ4, 3GJ5, 3GJ6, 3GJ7, 3GJ8, 3GJX, 3NBY, 3NBZ, 3NC0, 3NC1, 3ZJY, 4C0Q, 4GMX, 4GPT, 4HAT, 4HAU, 4HAV, 4HAW, 4HAX, 4HAY, 4HAZ, 4HB0, 4HB2, 4HB3, 4HB4, 4OL0, 4WVF, 5CIQ, 5CIT, 5CIW, 5CJ2, 5CLL, 5CLQ, 5DH9, 5DHA, 5DHF, 5DI9, 5DIF, 5DIS, 5DLQ, 5FYQ, 5JLJ, 5UWH, 5UWI, 5UWJ, 5UWO, 5UWP, 5UWQ, 5UWR, 5UWS, 5UWT, 5UWU, 5UWW,
pfam ID PF00071,
Drug Bank ID DB04315,
ChEMBL ID N.A.
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Sendai virus
Virus Short Name SeV
Order Mononegavirales
Virus Family Paramyxoviridae
Virus Subfamily N.A.
Genus Respirovirus
Species Murine respirovirus
Host Mammals
Cell Tropism N.A.
Associated Disease Acute febrile respiratory tract infection
Mode of Transmission Respiratory
VIPR DB link http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=paramyxo
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/negative-sense-rna-viruses-2011/w/negrna_viruses/199/paramyxoviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Paramyxoviridae

Publication Information

Paper Title Genome-wide RNAi screen reveals a new role of a WNT/ CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses
Author's Name Martin Baril, Salwa Es-Saad, Laurent Chatel-Chaix, Karin Fink, Tram Pham, Vale rie-Ann Raymond, Karine Audette, Anne-Sophie Guenier, Jean Duchaine, Marc Servant, Marc Bilodeau, E ric Cohen, Nathalie Grandvaux, Daniel Lamarre
Journal Name PLOS Pathogens
Pubmed ID 23785285
Abstract To identify new regulators of antiviral innate immunity, we completed the first genome-wide gene silencing screen assessing the transcriptional response at the interferon-beta (IFNB1) promoter following Sendai virus (SeV) infection. We now report a novel link between WNT signaling pathway and the modulation of retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-dependent innate immune responses. Here we show that secretion of WNT2B and WNT9B and stabilization of beta-catenin (CTNNB1) upon virus infection negatively regulate expression of representative inducible genes IFNB1, IFIT1 and TNF in a CTNNB1-dependent effector mechanism. The antiviral response is drastically reduced by glycogen synthase kinase 3 (GSK3) inhibitors but restored in CTNNB1 knockdown cells. The findings confirm a novel regulation of antiviral innate immunity by a canonical-like WNT/CTNNB1 signaling pathway. The study identifies novel avenues for broad-spectrum antiviral targets and preventing immune-mediated diseases upon viral infection.
Used Model HEK 293T and A549 cells
DOI 10.1371/journal.ppat.1003416