| Gene Name | N.A. |
| HF Protein Name | N.A. |
| HF Function | Inhibits Newcastle disease virus adsorption and replication |
| Uniprot ID | N.A. |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | N.A. |
| Host Factor (HF) Name in Paper | LGALS1 |
| Gene synonyms | N.A. |
| Ensemble Gene ID | N.A. |
| Ensemble Transcript | N.A. |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | N.A., |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | N.A. |
| PANTHER ID | N.A. |
| PDB ID(s) | N.A., |
| pfam ID | N.A., |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Gallus gallus (Chicken) |
| Virus Name | Newcastle disease virus |
| Virus Short Name | NDV |
| Order | Mononegavirales |
| Virus Family | Paramyxoviridae |
| Virus Subfamily | N.A. |
| Genus | Avulavirus |
| Species | Newcastle disease virus |
| Host | Birds |
| Cell Tropism | N.A. |
| Associated Disease | Variable fatal disease |
| Mode of Transmission | Direct contact with secretions from the nose, mouth, and eyes |
| VIPR DB link | http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=paramyxo |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/negative-sense-rna-viruses-2011/w/negrna_viruses/199/paramyxoviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Paramyxoviridae |
| Paper Title | Chicken galectin 1B inhibits Newcastle disease virus adsorption and replication through bindingto hemagglutinin-neuraminidase (HN) glycoprotein |
| Author's Name | Junfeng Sun, Zongxi Han, Tianming Qi, Ran Zhao, Shengwang Liu |
| Journal Name | Journal Of Biological Chemistry |
| Pubmed ID | 28978647 |
| Abstract | Galectin-1 is an important immunoregulatory factor and can mediate the host-pathogen interaction via binding glycans on the surface of various viruses. We previously reported that avian respiratory viruses, including lentogenic Newcastle disease virus (NDV), can induce up-regulation of chicken galectin (CG)-1B in the primary target organ. In this study, we investigated whether CG-1B participated in the infectious process of NDV in chickens. We demonstrated that velogenic NDV induced up-regulation of CG-1B in target organs. We also found that CG-1B directly bound to NDV virions and inhibited their hemagglutination activity in vitro We confirmed that CG-1B interacted with NDV hemagglutinin-neuraminidase (HN) glycoprotein, in which the specific G4 N-glycans significantly contributed to the interaction between CG-1B and HN glycoprotein. The presence of extracellular CG-1B, rather than the internalization process, inhibited adsorption of NDV. The interaction between intracellular CG-1B and NDV HN glycoproteins inhibited cell-surface expression of HN glycoprotein and reduced the titer of progeny virus in NDV-infected DF-1 cells. Significantly, the replication of parental and HN glycosylation mutant viruses in CG-1B knockdown and overexpression cells demonstrated that the replication of NDV was correlated with the expression of CG-1B in a specific glycan-dependent manner. Collectively, our results indicate that CG-1B has anti-NDV activity by binding to N-glycans on HN glycoprotein. |
| Used Model | DF-1 cells |
| DOI | 10.1074/jbc.M116.772897 |
