Virus Details


VHFID6782

Host Factor Information

Gene Name PPIA
HF Protein Name Peptidyl-prolyl cis-trans isomerase A
HF Function Helps in virus reinfection by targeting T-cell lymphokine production
Uniprot ID P62937
Protein Sequence View Fasta Sequence
NCBI Gene ID 5478
Host Factor (HF) Name in Paper CsA
Gene synonyms CYPA
Ensemble Gene ID ENSG00000196262
Ensemble Transcript ENST00000355968 [P62937-2];ENST00000468812 [P62937-1];ENST00000489459 [P62937-2];ENST00000620047 [P62937-2]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000413, GO:0003723, GO:0003755, GO:0005576, GO:0005615, GO:0005634, GO:0005829, GO:0005925, GO:0006278, GO:0006457, GO:0016018, GO:0016020, GO:0019058, GO:0019061, GO:0019064, GO:0019068, GO:0019076, GO:0030260, GO:0031982, GO:0032991, GO:0034389, GO:0034774, GO:0035722, GO:0043312, GO:0045069, GO:0045070, GO:0046790, GO:0050714, GO:0050900, GO:0051082, GO:0070062, GO:0075713, GO:1904813,
MINT ID P62937
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 123840
PANTHER ID PTHR11071
PDB ID(s) 1AK4, 1AWQ, 1AWR, 1AWS, 1AWT, 1AWU, 1AWV, 1BCK, 1CWA, 1CWB, 1CWC, 1CWF, 1CWH, 1CWI, 1CWJ, 1CWK, 1CWL, 1CWM, 1CWO, 1FGL, 1M63, 1M9C, 1M9D, 1M9E, 1M9F, 1M9X, 1M9Y, 1MF8, 1MIK, 1NMK, 1OCA, 1RMH, 1VBS, 1VBT, 1W8L, 1W8M, 1W8V, 1YND, 1ZKF, 2ALF, 2CPL, 2CYH, 2MS4, 2MZU, 2N0T, 2RMA, 2RMB, 2X25, 2X2A, 2X2C, 2X2D, 2XGY, 3CYH, 3CYS, 3K0M, 3K0N, 3K0O, 3K0P, 3K0Q, 3K0R, 3ODI, 3ODL, 3RDD, 4CYH, 4IPZ, 4N1M, 4N1N, 4N1O, 4N1P, 4N1Q, 4N1R, 4N1S, 4YUG, 4YUH, 4YUI, 4YUJ, 4YUK, 4YUL, 4YUM, 4YUN, 4YUO, 4YUP, 5CYH, 5F66, 5FJB, 5KUL, 5KUN, 5KUO, 5KUQ, 5KUR, 5KUS, 5KUU, 5KUV, 5KUW, 5KUZ, 5KV0, 5KV1, 5KV2, 5KV3, 5KV4, 5KV5, 5KV6, 5KV7, 5LUD, 5NOQ, 5NOR, 5NOS, 5NOT, 5NOU, 5NOV, 5NOW, 5NOX, 5NOY, 5NOZ, 5T9U, 5T9W, 5T9Z, 5TA2, 5TA4,
pfam ID PF00160,
Drug Bank ID DB01742, DB00091, DB02419, DB00172,
ChEMBL ID CHEMBL1949
Organism Homo sapiens (Human)

Pathogen Information

Virus Name ORF Virus
Virus Short Name ORF
Order Unassigned
Virus Family Poxviridae
Virus Subfamily Chordopoxvirinae
Genus Parapoxvirus
Species ORF Virus
Host Human, mammals
Cell Tropism N.A.
Associated Disease Skin lesions
Mode of Transmission Zoonosis, contact
VIPR DB link https://www.viprbrc.org/brc/home.spg?decorator=pox
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/74/poxviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Poxviridae

Publication Information

Paper Title Cyclosporin A abrogates the acquired immunity to cutaneous reinfection with the parapoxvirus orf virus
Author's Name D. McK. HAIG, C. J. McINNES, G. HUTCHISON, H.-F. SEOW & H. W. REID
Journal Name Immunology
Pubmed ID 9014816
Abstract The effect of cyclosporin A (CsA) on host immunity to cutaneous reinfection with the parapoxvirus orf virus was studied in 6-month-old lambs. In control reinfected animals, clinical lesions and viral replication (measured by the presence of vesicular/pustular lesions and viral antigen) in regenerating epidermal cells were at a maximum on day 4 with resolution by day 9. Lesion histology revealed recruitment of T cells, B cells and dermal dendritic cells (DDC) which increased and decreased in parallel with the clinical course of the reinfection. In animals treated with CsA (25 mg/kg/day) 1 day before and for 8 days after reinfection, more severe clinical lesions and viral replication typical of primary infections were recorded and had not resolved by 28 days following reinfection. During CsA treatment, the recruitment of T cells, B cells and DDC was inhibited. With cessation of CsA treatment there was dramatic recruitment of CD4+ T cells followed by DDC then B cells to the lesion site but rapid onset of acquired immunity was not recorded. Reverse transcription-polymerase chain reaction (RT-PCR) analysis of cytokine mRNAs from lesion biopsies showed individual sheep variations. However, interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) mRNAs were detected in the control reinfected animals on days 3 and/or 9 after reinfection but not on these days in animals undergoing treatment with CsA. In the untreated lambs there was an inexplicable lack of IL-2 and IFN-gamma mRNAs on day 6 after reinfection. Tumour necrosis factor-alpha (TNF-alpha) and vascular endothelial growth factor (VEGF) mRNAs were unaffected by CsA treatment. The data suggest that CsA abrogates acquired immunity to orf virus reinfection by targetting T-cell lymphokine production.
Used Model Suffolk-cross lambs
DOI 10.1046/j.1365-2567.1996.940967.x