| Gene Name | LSm14A |
| HF Protein Name | LSm14A |
| HF Function | Inhibits virus replication |
| Uniprot ID | R4JU57 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 100511455 |
| Host Factor (HF) Name in Paper | LSM14A |
| Gene synonyms | LSM14A |
| Ensemble Gene ID | ENSSSCG00000002869 |
| Ensemble Transcript | ENSSSCT00000055533 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000932, GO:0003690, GO:0003725, GO:0003727, GO:0005829, GO:0010494, GO:0033962, GO:0039529, GO:0060340, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | N.A. |
| PANTHER ID | N.A. |
| PDB ID(s) | N.A., |
| pfam ID | PF09532, PF12701, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Sus scrofa (Pig) |
| Virus Name | Porcine reproductive and respiratory syndrome virus |
| Virus Short Name | PRRSV |
| Order | Nidovirales |
| Virus Family | Arteriviridae |
| Virus Subfamily | N.A. |
| Genus | Porartevirus |
| Species | Porcine reproductive and respiratory syndrome virus |
| Host | Vertebrates |
| Cell Tropism | Primarily it's found in alveolar lung macrophages and macrophages of other tissues, later, is also found in testicular germ cells. |
| Associated Disease | Abortions and respiratory disease |
| Mode of Transmission | Transplacental, saliva, urine, semen and respiratory tract secretions |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/positive-sense-rna-viruses-2011/w/posrna_viruses/220/arteriviridae |
| Virus Host DB link | N.A. |
| Paper Title | LSM14A inhibits porcine reproductive and respiratory syndrome virus (PRRSV) replication by activating IFN-b signaling pathway in Marc-145 |
| Author's Name | Zhenhong Li, Rui Chen, Jinhua Zhao, Ziyu Qi, Likai Ji, Yueran Zhen, Bang Liu |
| Journal Name | Molecular and Cellular Biochemistry |
| Pubmed ID | 25408553 |
| Abstract | Porcine reproductive and respiratory syndrome virus (PRRSV) is considered as a significant contributor to porcine reproductive and respiratory syndrome, one of the most economically important diseases for the pig industry worldwide. Emerging evidence indicates that pattern recognition receptors play key roles in recognizing pathogen-associated molecular patterns. In the present study, we investigated the effects of a novel pattern recognition receptor LSM14A in regulating PRRSV replication. Results in Marc-145 cells and porcine alveolar macrophages (PAMs) indicated that overexpression of porcine LSM14A effectively inhibited the replication of PRRSV, and knockdown of LSM14A by siRNA enhanced the replication of PRRSV. Mechanistically, LSM14A up-regulated the activities of IFN-beta and ISRE promoters, enhanced the production of IFN-beta, RIG-I, and ISGs, and inhibited the production of the inflammatory cytokines of TNF-alpha and IL-6 mRNA. Additionally, the expression pattern of LSM14A during the infection of PRRSV in Tongcheng and Large White pigs was suppressed by the PRRSV challenge. Taken together, our results suggest that LSM14A is an important PRR that inhibitsPPRSV replication by inducing IFN-beta signaling and restraining inflammatory responses. Furthermore, the down-regulation of LSM14Aby PRRSV might represent an important mechanism by which PRRSV invades the host. Our study sheds light on the possibility of developing a new strategy to control this disease. |
| Used Model | MARC-145 cells |
| DOI | 10.1007/s11010-014-2251-8 |
