| Gene Name | NCAM1 |
| HF Protein Name | Neural cell adhesion molecule 1 |
| HF Function | Receptor for Rabies virus |
| Uniprot ID | P13591 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 4684 |
| Host Factor (HF) Name in Paper | NCAM1 |
| Gene synonyms | NCAM |
| Ensemble Gene ID | ENSG00000149294 |
| Ensemble Transcript | ENST00000316851 [P13591-2];ENST00000529356 [P13591-6];ENST00000531044 [P13591-1];ENST00000621128 [P13591-4];ENST00000621850 [P13591-3] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000139, GO:0000165, GO:0001618, GO:0005088, GO:0005829, GO:0005886, GO:0007155, GO:0007411, GO:0009897, GO:0009986, GO:0016020, GO:0016021, GO:0031012, GO:0031225, GO:0042802, GO:0060333, GO:0070062, |
| MINT ID | P13591 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 116930 |
| PANTHER ID | PTHR44059:SF2 |
| PDB ID(s) | 2E3V, 2HAZ, 2VKW, 2VKX, 3MTR, 5AEA, 5LKN, |
| pfam ID | PF00041, PF07679, |
| Drug Bank ID | N.A., |
| ChEMBL ID | CHEMBL3712938 |
| Organism | Homo sapiens (Human) |
| Virus Name | Rabies virus |
| Virus Short Name | RABV |
| Order | Mononegavirales |
| Virus Family | Rhabdoviridae |
| Virus Subfamily | N.A. |
| Genus | Lyssavirus |
| Species | Rabies lyssavirus |
| Host | Human, mammals |
| Cell Tropism | N.A. |
| Associated Disease | Rabies fatal encephalitis |
| Mode of Transmission | Zoonosis, animal bite |
| VIPR DB link | https://www.viprbrc.org/brc/vipr_allSpecies_search.spg?method=SubmitForm&decorator=rhabdo |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/negative-sense-rna-viruses-2011/w/negrna_viruses/201/rhabdoviridae |
| Virus Host DB link | N.A. |
| Paper Title | The Neural Cell Adhesion Molecule Is a Receptor for Rabies Virus |
| Author's Name | MARIA-ISABEL THOULOUZE, MIREILLE LAFAGE, MELITTA SCHACHNER, URSULA HARTMANN, HAROLD CREMER AND MONIQUE LAFON |
| Journal Name | Journal Of Virology |
| Pubmed ID | 9696812 |
| Abstract | Previous reports strongly suggest that, in addition to the nicotinic acetylcholine receptor, rabies virus can use other, as-yet-unidentified receptors. We found that laboratory cell lines susceptible to rabies virus infection express the neural cell adhesion molecule (NCAM) (CD56) on their surface, whereas resistant cells do not, supporting the idea that NCAM could be a rabies virus receptor. We observed that (i) incubation with rabies virus decreases the surface expression of NCAM (ii) treatment of susceptible cells with heparan sulfate, a ligand for NCAM, or with NCAM antibodies significantly reduces the rabies virus infection and (iii) preincubation of rabies virus inoculum with soluble NCAM protein as a receptor decoy drastically neutralizes the capacity of rabies virus to infect susceptible cells. Moreover, we demonstrated that transfection of resistant L fibroblasts with the NCAM-encoding gene induces rabies virus susceptibility whereas absence of NCAM in the primary cortical cell cultures prepared from NCAM-deficient mice reduces the rabies virus infection and virus production. This provides evidence that NCAM is an in vitro receptor for the rabies virus. Moreover, the in vivo relevance for the use of NCAM as a receptor was demonstrated by the infection of NCAM-deficient mice, in which rabies mortality was delayed and brain invasion by rabies virus was drastically restricted. Our results showed that NCAM, which is expressed mainly in the adult nervous system, plays an important role in rabies infection. However, it cannot be excluded that receptors other than NCAM are utilized. Thus, the description of NCAM as a new rabies virus receptor would be another example of the use by viruses of more than one receptor to gain entry into the host. |
| Used Model | NCAM-deficient mice |
| DOI | NA |
