| Gene Name | NLRP3 |
| HF Protein Name | NACHT, LRR and PYD domains-containing protein 3 |
| HF Function | Recognizes Rabies Virus and activates Interleukin-1beta release in Murine Dendritic Cells |
| Uniprot ID | Q96P20 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 114548 |
| Host Factor (HF) Name in Paper | NLRP3 |
| Gene synonyms | C1orf7 CIAS1 NALP3 PYPAF1 |
| Ensemble Gene ID | ENSG00000162711 |
| Ensemble Transcript | ENST00000336119 [Q96P20-1];ENST00000348069 [Q96P20-2];ENST00000366496 [Q96P20-5];ENST00000366497 [Q96P20-5];ENST00000391827 [Q96P20-4];ENST00000391828 [Q96P20-1] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0002374, GO:0002674, GO:0002830, GO:0005524, GO:0005576, GO:0005634, GO:0005737, GO:0005783, GO:0005829, GO:0006351, GO:0006915, GO:0006919, GO:0006952, GO:0006954, GO:0007165, GO:0008134, GO:0009595, GO:0016579, GO:0032088, GO:0032611, GO:0032621, GO:0032736, GO:0032753, GO:0032754, GO:0042347, GO:0042802, GO:0042834, GO:0043280, GO:0043565, GO:0044546, GO:0045087, GO:0045630, GO:0045944, GO:0050701, GO:0050713, GO:0050718, GO:0050728, GO:0050830, GO:0051092, GO:0051259, GO:0051607, GO:0071222, GO:0071224, GO:0072559, GO:2000321, GO:2000553, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 120100 |
| PANTHER ID | N.A. |
| PDB ID(s) | 2NAQ, 3QF2, |
| pfam ID | PF14484, PF13516, PF02758, |
| Drug Bank ID | N.A., |
| ChEMBL ID | CHEMBL1741208 |
| Organism | Homo sapiens (Human) |
| Virus Name | Rabies virus |
| Virus Short Name | RABV |
| Order | Mononegavirales |
| Virus Family | Rhabdoviridae |
| Virus Subfamily | N.A. |
| Genus | Lyssavirus |
| Species | Rabies lyssavirus |
| Host | Human, mammals |
| Cell Tropism | N.A. |
| Associated Disease | Rabies fatal encephalitis |
| Mode of Transmission | Zoonosis, animal bite |
| VIPR DB link | https://www.viprbrc.org/brc/vipr_allSpecies_search.spg?method=SubmitForm&decorator=rhabdo |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/negative-sense-rna-viruses-2011/w/negrna_viruses/201/rhabdoviridae |
| Virus Host DB link | N.A. |
| Paper Title | Rabies virus Is recognized by the NLRP3 inflammasome and activates interleukin-1beta release in murine dendritic cells |
| Author's Name | Tessa M. Lawrence, Andrew W. Hudacek, Marcel R. de Zoete, Richard A. Flavell, Matthias J. Schnell |
| Journal Name | Journal Of Virology |
| Pubmed ID | 23487464 |
| Abstract | Inflammasome activation is important for the development of an effective host defense against many pathogens, including RNA viruses. However, the mechanism by which the inflammasome recognizes RNA viruses and its role in rabies virus (RABV) pathogenicity and immunogenicity remain poorly defined. To determine the function of the inflammasome in response to RABV infection, we infected murine bone marrow-derived dendritic cells (BMDCs) with RABV. Our results indicate that the infection of BMDCs with RABV induces both the production of pro-interleukin-1beta (pro-IL-1beta) and its processing, resulting in the secretion of active IL-1beta through activation of the NLRP3-, ASC-, and caspase-1-dependent inflammasome. As previously shown for the induction of type I interferon by RABV, the induction of pro-IL-1beta also depends upon IPS-1. We demonstrate that both the production of pro-IL-1beta and activation of the inflammasome require viral replication. We also demonstrate that increased viral replication in BMDCs derived from IFNAR-deficient mice resulted in significantly more IL-1beta release. Additionally, IL-1 receptor-deficient mice show an increase in RABV pathogenicity. Taken together, these results indicate an important role of the inflammasome in innate immune recognition of RABV. |
| Used Model | BALB/c, C57BL/6, IPS-1, deficient in NLRP3, ASC (Pycard/CARD5) and caspase-1/11 Mice |
| DOI | 10.1128/JVI.00203-13 |
