| Gene Name | MOG |
| HF Protein Name | Myelin-oligodendrocyte glycoprotein |
| HF Function | Cellular receptor of Rubella Virus |
| Uniprot ID | Q16653 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 4340 |
| Host Factor (HF) Name in Paper | MOG |
| Gene synonyms | N.A. |
| Ensemble Gene ID | ENSG00000137345 |
| Ensemble Transcript | ENST00000259891;ENST00000359539;ENST00000376888 [Q16653-4];ENST00000376891 [Q16653-11];ENST00000376894 [Q16653-13];ENST00000376898 [Q16653-5];ENST00000376917 [Q16653-1];ENST00000383521;ENST00000383525;ENST00000383630;ENST00000383631;ENST00000396701 [Q16653-6];ENST00000396704 [Q16653-3];ENST00000400669;ENST00000400671;ENST00000400688;ENST00000400691;ENST00000412760;ENST00000414889;ENST00000415546;ENST00000417019;ENST00000419274;ENST00000419309;ENST00000420045;ENST00000423895;ENST00000425145;ENST00000426782;ENST00000427289;ENST00000428719;ENST00000430264;ENST00000430351;ENST00000431798 [Q16653-2];ENST00000432271;ENST00000433500;ENST00000434177;ENST00000438803;ENST00000439634;ENST00000439884;ENST00000440561;ENST00000442244;ENST00000442444;ENST00000442629;ENST00000444674;ENST00000447285;ENST00000448816;ENST00000449096;ENST00000452233;ENST00000452744;ENST00000457090;ENST00000457626;ENST00000458179;ENST00000490427 [Q16653-12];ENST00000494692 [Q16653-7];ENST00000547083;ENST00000548017;ENST000 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0001618, GO:0005886, GO:0007155, GO:0007417, GO:0016021, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 159465 |
| PANTHER ID | N.A. |
| PDB ID(s) | 1Q70, |
| pfam ID | PF07686, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Rubella virus |
| Virus Short Name | RuV |
| Order | Unassigned |
| Virus Family | Togaviridae |
| Virus Subfamily | N.A. |
| Genus | Rubivirus |
| Species | Rubella virus |
| Host | Human |
| Cell Tropism | N.A. |
| Associated Disease | Rubella |
| Mode of Transmission | By respiratory droplets and sliva |
| VIPR DB link | https://www.viprbrc.org/brc/vipr_allSpecies_search.spg?method=SubmitForm&decorator=toga |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/positive-sense-rna-viruses-2011/w/posrna_viruses/275/togaviridae |
| Virus Host DB link | N.A. |
| Paper Title | Identification of the myelin oligodendrocyte glycoprotein as a cellular receptor for rubella Virus |
| Author's Name | Haolong Cong, Yue Jiang and Po Tien |
| Journal Name | JOURNAL OF VIROLOGY |
| Pubmed ID | 21880773 |
| Abstract | Rubella virus (RV) is a highly transmissible pathogenic agent that causes the disease rubella. Maternal RV infection during early pregnancy causes the death of the fetus or congenital rubella syndrome in infants. However, the cellular receptor for RV has not yet been identified. In this study, we found that the myelin oligodendrocyte glycoprotein (MOG) specifically bound to the E1 envelope glycoprotein of RV, and an antibody against MOG could block RV infection. Most importantly, we also showed that ectopic expression of MOG on the cell surface of 293T cells rendered this nonpermissive cell line permissive for RV entry and replication. Thus, this study has identified a cellular receptor for RV and suggests that blocking the MOG attachment site of RV may be a strategy for molecular intervention of RV infection. |
| Used Model | 293T, BHK21 and MRC-5 cells |
| DOI | 10.1128/JVI.05398-11 |
