| Gene Name | KIN |
| HF Protein Name | DNA/RNA-binding protein KIN17 |
| HF Function | Inhibits DNA replication |
| Uniprot ID | O60870 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 22944 |
| Host Factor (HF) Name in Paper | Kin17 |
| Gene synonyms | BTCD KIN17 |
| Ensemble Gene ID | ENSG00000151657 |
| Ensemble Transcript | ENST00000379562 [O60870-1] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0003677, GO:0003690, GO:0003723, GO:0005634, GO:0005654, GO:0005737, GO:0006260, GO:0006281, GO:0006310, GO:0006397, GO:0006479, GO:0006974, GO:0016032, GO:0016363, GO:0032991, GO:0043231, GO:0046872, |
| MINT ID | O60870 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 601720 |
| PANTHER ID | PTHR12805 |
| PDB ID(s) | 2CKK, 2V1N, |
| pfam ID | PF10357, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Simian Virus 40 |
| Virus Short Name | SV40 |
| Order | Unassigned |
| Virus Family | Polyomaviridae |
| Virus Subfamily | N.A. |
| Genus | Betapolyomavirus |
| Species | Simian virus 40 |
| Host | Mammals, human |
| Cell Tropism | N.A. |
| Associated Disease | N.A. |
| Mode of Transmission | N.A. |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/129/polyomaviridae |
| Virus Host DB link | N.A. |
| Paper Title | Human Kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication |
| Author's Name | Laurent Miccoli, Denis S. F. Biard, Christophe Créminon and Jaime F. Angulo |
| Journal Name | Cancer Research |
| Pubmed ID | 12359749 |
| Abstract | Kin17 is an evolutionarily conserved DNA-binding protein, which forms intranuclear foci in proliferating cells. Recent data have suggested that human kin17 protein is associated with cell proliferation and unrepaired DNA lesions. Herein, we show that human fibroblasts (MRC5-V2 and CHSV4) immortalized with SV40 overexpress endogenous kin17 protein, as compared with normal diploid human fibroblasts. We observed that certain carcinoma cell lines also up-regulated kin17 protein, suggesting that increased kin17 protein levels may be a consequence of the immortalized phenotype. We report here that the endogenous kin17 protein is located in nucleoplasmic foci and colocalizes with SV40 large T antigen. Purification of human kin17 protein allowed analysis of the physical interaction with T antigen by several in vitro and in vivo assays. Large T antigen and human kin17 protein are part of the same high molecular weight multiprotein complex in human cells. Furthermore, human kin17 protein interacts with T antigen bound to the SV40 DNA origin of replication. Strikingly, the overexpression of human kin17 protein in vivo and the introduction of increased amounts of human kin17 protein in an in vitro assay reduced T-antigen-dependent DNA replication, suggesting that kin17 protein may be involved in the DNA replication process in human cells. |
| Used Model | Sf9, MRC5-V2 and HEK 293 cells |
| DOI | N.A. |
