| Gene Name | POU2F2 |
| HF Protein Name | POU domain, class 2, transcription factor 2 |
| HF Function | Regulates viral replication |
| Uniprot ID | P09086 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 5452 |
| Host Factor (HF) Name in Paper | 2-Oct |
| Gene synonyms | OCT2 OTF2 |
| Ensemble Gene ID | ENSG00000028277 |
| Ensemble Transcript | ENST00000389341 [P09086-3];ENST00000526816 [P09086-1];ENST00000529067 [P09086-4];ENST00000529952 [P09086-2] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000978, GO:0000981, GO:0001077, GO:0002335, GO:0002380, GO:0003700, GO:0005634, GO:0005654, GO:0005737, GO:0006366, GO:0006959, GO:0019904, GO:0042795, GO:0043231, GO:0043565, GO:0048469, |
| MINT ID | P09086 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 164176 |
| PANTHER ID | N.A. |
| PDB ID(s) | 1HDP, |
| pfam ID | PF00046, PF00157, |
| Drug Bank ID | DB08930, |
| ChEMBL ID | CHEMBL3509582 |
| Organism | Homo sapiens (Human) |
| Virus Name | Simian Virus 40 |
| Virus Short Name | SV40 |
| Order | Unassigned |
| Virus Family | Polyomaviridae |
| Virus Subfamily | N.A. |
| Genus | Betapolyomavirus |
| Species | Simian virus 40 |
| Host | Mammals, human |
| Cell Tropism | N.A. |
| Associated Disease | N.A. |
| Mode of Transmission | N.A. |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/129/polyomaviridae |
| Virus Host DB link | N.A. |
| Paper Title | Transcription factor oct1 binds to the AT-rich segment of the simian virus 40 replication origin |
| Author's Name | JOCHEN KILWINSKI, MARTINA BAACK, SUSANNE HEILAND, AND ROLF KNIPPERS |
| Journal Name | Journal Of Virology |
| Pubmed ID | 7983758 |
| Abstract | A cellular protein that binds to the AT-rich late segment of the simian virus 40 (SV40) origin of replication has been identified as transcription factor Oct1. This conclusion is based on the following observations: the late origin binding protein has a molecular mass of about 100 kDa, like factor Oct1, and shares other biochemical properties with Oct1 its binding to the origin is inhibited by antibodies directed against the POU domain of factor Oct1 the isolated POU domain of Oct1 specifically binds to the SV40 late origin region. Thus, the SV40 genome contains binding sites for transcription factor Oct1 in the origin of replication in addition to the previously characterized octamer sites in the viral promoter enhancer. Oct1, bound to the viral origin, negatively affects the DNA unwinding reaction catalyzed by the viral replication initiator T antigen, suggesting that Oct1 may have a role in the regulation of viral replication. |
| Used Model | Hela cells |
| DOI | N.A. |
