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Virus Details


VHFID7338

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name RB1
HF Protein Name Retinoblastoma-associated protein
HF Function Antiviral protein
Uniprot ID P06400
Protein Sequence View Fasta Sequence
NCBI Gene ID 5925
Host Factor (HF) Name in Paper Rb
Gene synonyms N.A.
Ensemble Gene ID ENSG00000139687
Ensemble Transcript ENST00000267163
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000082, GO:0000122, GO:0000785, GO:0001047, GO:0001102, GO:0001558, GO:0001894, GO:0003677, GO:0003700, GO:0003713, GO:0005634, GO:0005654, GO:0005819, GO:0006338, GO:0006351, GO:0006355, GO:0006469, GO:0007050, GO:0007093, GO:0007265, GO:0007346, GO:0008134, GO:0010629, GO:0016032, GO:0016514, GO:0016605, GO:0019900, GO:0030521, GO:0031134, GO:0031175, GO:0031625, GO:0034088, GO:0034349, GO:0035189, GO:0035914, GO:0042551, GO:0042802, GO:0043353, GO:0043433, GO:0043550, GO:0045445, GO:0045651, GO:0045842, GO:0045879, GO:0045892, GO:0045893, GO:0045944, GO:0048565, GO:0048667, GO:0050680, GO:0050681, GO:0051146, GO:0051219, GO:0051301, GO:0051402, GO:0061676, GO:0071459, GO:0071466, GO:0071922, GO:0071930, GO:0090230, GO:0097284, GO:0097718, GO:2000134, GO:2000679,
MINT ID P06400
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 109800
PANTHER ID PTHR13742;PTHR13742:SF17
PDB ID(s) 1AD6, 1GH6, 1GUX, 1H25, 1N4M, 1O9K, 1PJM, 2AZE, 2QDJ, 2R7G, 3N5U, 3POM, 4CRI, 4ELJ, 4ELL,
pfam ID PF11934, PF01858, PF01857, PF08934,
Drug Bank ID DB00030, DB00071,
ChEMBL ID CHEMBL5288
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Simian Virus 40
Virus Short Name SV40
Order Unassigned
Virus Family Polyomaviridae
Virus Subfamily N.A.
Genus Betapolyomavirus
Species Simian virus 40
Host Mammals, human
Cell Tropism N.A.
Associated Disease N.A.
Mode of Transmission N.A.
VIPR DB link N.A.
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/129/polyomaviridae
Virus Host DB link N.A.

Publication Information

Paper Title PP2A-dependent disruption of centrosome replication and cytoskeleton organization in Drosophila by SV40 small tumor antigen
Author's Name S Kotadia, LR Kao, SA Comerford, RT Jones, RE Hammer and TL Megraw
Journal Name Oncogene
Pubmed ID 18663356
Abstract Viruses of the DNA tumor virus family share the ability to transform vertebrate cells through the action of virus-encoded tumor antigens that interfere with normal cell physiology. They accomplish this very efficiently by inhibiting endogenous tumor suppressor proteins that control cell proliferation and apoptosis. Simian virus 40 (SV40) encodes two oncoproteins, large tumor antigen, which directly inhibits the tumor suppressors p53 and Rb, and small tumor antigen (ST), which interferes with serine/threonine protein phosphatase 2A (PP2A). We have constructed a Drosophila model for SV40 ST expression and show that ST induces supernumerary centrosomes, an activity we also demonstrate in human cells. In early Drosophila embryos, ST also caused increased microtubule stability, chromosome segregation errors, defective assembly of actin into cleavage furrows, cleavage failure, a rise in cyclin E levels and embryonic lethality. Using ST mutants and genetic interaction experiments between ST and PP2A subunit mutations, we show that all of these phenotypes are dependent on STs interaction with PP2A. These analyses demonstrate the validity and utility of Drosophila as a model for viral oncoprotein function in vivo.
Used Model U2OS cells
DOI 10.1038/onc.2008.254