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Virus Details


VHFID7458

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name SLC11A2
HF Protein Name Natural resistance-associated macrophage protein 2
HF Function Cellular receptor for Sindbis virus
Uniprot ID P49281
Protein Sequence View Fasta Sequence
NCBI Gene ID 4891
Host Factor (HF) Name in Paper NRAMP2
Gene synonyms DCT1 DMT1 NRAMP2
Ensemble Gene ID ENSG00000110911
Ensemble Transcript ENST00000262051 [P49281-1];ENST00000262052 [P49281-2];ENST00000394904 [P49281-3];ENST00000541174 [P49281-2];ENST00000545993 [P49281-5];ENST00000546636 [P49281-1];ENST00000547198 [P49281-1];ENST00000547688 [P49281-3]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0001666, GO:0003032, GO:0005375, GO:0005381, GO:0005384, GO:0005385, GO:0005634, GO:0005737, GO:0005739, GO:0005741, GO:0005764, GO:0005765, GO:0005769, GO:0005770, GO:0005773, GO:0005802, GO:0005886, GO:0005887, GO:0006783, GO:0006824, GO:0006825, GO:0006828, GO:0006879, GO:0006919, GO:0007611, GO:0009986, GO:0010039, GO:0015086, GO:0015087, GO:0015093, GO:0015094, GO:0015099, GO:0015100, GO:0015295, GO:0015675, GO:0015676, GO:0015684, GO:0015692, GO:0016020, GO:0016324, GO:0022890, GO:0031410, GO:0031526, GO:0031902, GO:0034599, GO:0045177, GO:0045178, GO:0046870, GO:0046915, GO:0048471, GO:0048813, GO:0048821, GO:0055037, GO:0060586, GO:0070574, GO:0070627, GO:0070826, GO:1903561, GO:1903874,
MINT ID N.A.
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 206100
PANTHER ID PTHR11706
PDB ID(s) 5F0L, 5F0M, 5F0P,
pfam ID PF01566,
Drug Bank ID N.A.,
ChEMBL ID CHEMBL1932895
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Sindbis virus
Virus Short Name SINV
Order Unassigned
Virus Family Togaviridae
Virus Subfamily N.A.
Genus Alphavirus
Species Sindbis virus
Host Human, mammals,mosquitoes and birds
Cell Tropism N.A.
Associated Disease Sindbis fever
Mode of Transmission By infected mosquito
VIPR DB link https://www.viprbrc.org/brc/vipr_allSpecies_search.spg?method=SubmitForm&decorator=toga
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/positive-sense-rna-viruses-2011/w/posrna_viruses/275/togaviridae
Virus Host DB link N.A.

Publication Information

Paper Title Natural Resistance-associated macrophage protein (NRAMP) is a cellular receptor for sindbis virus in both insect and mammalian hosts
Author's Name Patrick P. Rose, Sheri L. Hanna, Anna Spiridigliozzi, Nattha Wannissorn, Daniel P. Beiting, Susan R. Ross, Richard W. Hardy, Shelly A. Bambina, Mark T. Heise, and Sara Cherry
Journal Name Cell Host & Microbe
Pubmed ID 21843867
Abstract Alphaviruses, including several emerging human pathogens, are a large family of mosquito-borne viruses with Sindbis virus being a prototypical member of the genus. The host factor requirements and receptors for entry of this class of viruses remain obscure. Using a Drosophila system, we identified the divalent metal ion transporter natural resistance-associated macrophage protein (NRAMP) as a host cell surface molecule required for Sindbis virus binding and entry into Drosophila cells. Consequently, flies mutant for dNRAMP were protected from virus infection. NRAMP2, the ubiquitously expressed vertebrate homolog, mediated binding and infection of Sindbis virus into mammalian cells, and murine cells deficient for NRAMP2 were nonpermissive to infection. Alphavirus glycoprotein chimeras demonstrated that the requirement for NRAMP2 is at the level of Sindbis virus entry. Given the conserved structure of alphavirus glycoproteins, and the widespread use of transporters for viral entry, other alphaviruses may use conserved multipass membrane proteins for infection.
Used Model Kc167
DOI 10.1016/j.chom.2011.06.009