| Virus Name | Tick-borne encephalitis virus |
| Virus Short Name | TBEV |
| Order | Unassigned |
| Virus Family | Flaviviridae |
| Virus Subfamily | N.A. |
| Genus | Flavivirus |
| Species | Tick-borne encephalitis virus |
| Host | Human, mammals, mosquitoes and ticks |
| Cell Tropism | N.A. |
| Associated Disease | Meningitis and encephalitis |
| Mode of Transmission | Tick bite,from an infected mother to fetus |
| VIPR DB link | http://www.viprbrc.org/brc/home.spg?decorator=flavi |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/flaviviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Flaviviridae |
| Paper Title | Protective role of TNF-alpha, IL-10 and IL-2 in mice infected with the Oshima strain of Tick-borne encephalitis virus |
| Author's Name | Mya Myat Ngwe Tun, Kotaro Aoki, Masachika Senba, Corazon C. Buerano, Kenji Shirai, Ryuji Suzuki, Kouichi Morita and Daisuke Hayasaka |
| Journal Name | Scientific Reports |
| Pubmed ID | 24938868 |
| Abstract | Tick-borne encephalitis virus (TBEV) causes acute central nervous system disease. Here, we investigated the roles of the TNF-alpha, IL-10 and other cytokines in appropriate KO mice following infection with Oshima and Sofjin strains of TBEV. Following infection with the Oshima strain, mortality rates were significantly increased in TNF-alpha KO and IL-10 KO mice compared with wild type (WT) mice. These results suggested that TNF-alpha and IL-10 play protective roles against fatal infection due to Oshima strain infection. However, viral loads and proinflammatory cytokine levels in the brain of TNF-alpha KO andIL-10 KO mice were not significantly different compared with those of WT mice. On the other hand, all WT, TNF-alpha KO and IL-10 KO mice died following infection with Sofjin strain. Interestingly, Sofjin-infected mice did not exhibit an up-regulated mRNA level of IL-2 in the spleen in all groups of mice, whereas Oshima-infected mice showed significantly increased level of IL-2 compared with mock-infected mice. From these results, we suggest that TNF-alpha, IL-10 and IL-2 are key factors for disease remission from fatal encephalitis due to infection with Oshima strain of TBEV. |
| Used Model | C57BL/6j wild type mice and BHK cells |
| DOI | 10.1038/srep05346 |
