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Virus Details


VHFID7481

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name RAB1A
HF Protein Name Ras-related protein Rab-1A
HF Function Essential for viral DNA replication
Uniprot ID P62820
Protein Sequence View Fasta Sequence
NCBI Gene ID 5861
Host Factor (HF) Name in Paper RAB1A
Gene synonyms RAB1
Ensemble Gene ID ENSG00000138069
Ensemble Transcript ENST00000398529 [P62820-3];ENST00000409784 [P62820-1];ENST00000409892 [P62820-2]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000045, GO:0000139, GO:0003924, GO:0005525, GO:0005769, GO:0005789, GO:0005794, GO:0005829, GO:0006888, GO:0006890, GO:0006897, GO:0006914, GO:0007030, GO:0016192, GO:0016477, GO:0019068, GO:0030252, GO:0030658, GO:0032402, GO:0034446, GO:0042470, GO:0042742, GO:0043687, GO:0045296, GO:0047496, GO:0048208, GO:0070062, GO:0072606, GO:0090110, GO:1903020, GO:1904668,
MINT ID P62820
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 179508
PANTHER ID N.A.
PDB ID(s) 2FOL, 2WWX, 3L0I, 3SFV, 3TKL, 4FMB, 4FMC, 4FMD, 4FME, 4IRU, 4JVS,
pfam ID PF00071,
Drug Bank ID N.A.,
ChEMBL ID N.A.
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Vaccinia Virus
Virus Short Name VACV
Order Unassigned
Virus Family Poxviridae
Virus Subfamily Chordopoxvirinae
Genus Orthopoxvirus
Species Vaccinia virus
Host Human, mammals
Cell Tropism Dendritic cells, monocytes/macrophages, b lymphocytes, activated t lymphocytes
Associated Disease N.A.
Mode of Transmission N.A.
VIPR DB link https://www.viprbrc.org/brc/home.spg?decorator=pox
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/74/poxviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Poxviridae

Publication Information

Paper Title RAB1A promotes Vaccinia virus replication by facilitating the production of intracellular enveloped virions
Author's Name Tali Pechenick Jowers, Rebecca J. Featherstone, Danielle K. Reynolds, Helen K. Brown, John James, Alan Prescott, Ismar R. Haga and Philippa M. Beard
Journal Name Virology
Pubmed ID 25462347
Abstract Vaccinia virus (VACV) is a large double-stranded DNA virus with a complex cytoplasmic replication cycle that exploits numerous cellular proteins. This work characterises the role of a proviral cellular protein, the small GTPase RAB1A, in VACV replication. Using siRNA, we identified RAB1A as required for the production of extracellular enveloped virions (EEVs), but not intracellular mature virions (IMVs). Immunofluorescence and electron microscopy further refined the role of RAB1A as facilitating the wrapping of IMVs to become intracellular enveloped virions (IEVs). This is consistent with the known function of RAB1A in maintenance of ER to Golgi transport. VACV can therefore be added to the growing list of viruses which require RAB1A for optimal replication, highlighting this protein as a broadly proviral host factor.
Used Model BS-C-1 and hela cells
DOI 10.1016/j.virol.2014.11.007