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Virus Details


VHFID7671

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name STAT1
HF Protein Name Signal transducer and activator of transcription 1-alpha/beta
HF Function Antiviral protein
Uniprot ID P42224
Protein Sequence View Fasta Sequence
NCBI Gene ID 6772
Host Factor (HF) Name in Paper STAT1
Gene synonyms N.A.
Ensemble Gene ID ENSG00000115415
Ensemble Transcript ENST00000361099 [P42224-1];ENST00000392322 [P42224-2];ENST00000409465 [P42224-1]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000122, GO:0000790, GO:0000978, GO:0000979, GO:0000981, GO:0000982, GO:0000983, GO:0001047, GO:0001937, GO:0002053, GO:0002230, GO:0003340, GO:0003690, GO:0003700, GO:0004871, GO:0005164, GO:0005634, GO:0005654, GO:0005730, GO:0005737, GO:0005829, GO:0006351, GO:0007221, GO:0007259, GO:0007584, GO:0008015, GO:0009612, GO:0010742, GO:0016032, GO:0016525, GO:0019221, GO:0019899, GO:0030424, GO:0030425, GO:0031730, GO:0032727, GO:0032869, GO:0032991, GO:0033209, GO:0034097, GO:0035035, GO:0035257, GO:0035456, GO:0035458, GO:0038114, GO:0042393, GO:0042542, GO:0042802, GO:0042803, GO:0042981, GO:0043124, GO:0043434, GO:0044389, GO:0045296, GO:0045648, GO:0045893, GO:0045944, GO:0046725, GO:0048471, GO:0048661, GO:0051591, GO:0051607, GO:0051721, GO:0051770, GO:0060333, GO:0060334, GO:0060337, GO:0060338, GO:0061326, GO:0070102, GO:0070106, GO:0070491, GO:0070757, GO:0071346, GO:0071407, GO:0072136, GO:0072162, GO:0072308, GO:1990841,
MINT ID P42224
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 600555
PANTHER ID PTHR11801
PDB ID(s) 1BF5, 1YVL, 2KA6, 3WWT,
pfam ID PF00017, PF12162, PF01017, PF02864, PF02865,
Drug Bank ID N.A.,
ChEMBL ID CHEMBL6101
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Vaccinia Virus
Virus Short Name VACV
Order Unassigned
Virus Family Poxviridae
Virus Subfamily Chordopoxvirinae
Genus Orthopoxvirus
Species Vaccinia virus
Host Human, mammals
Cell Tropism Dendritic cells, monocytes/macrophages, b lymphocytes, activated t lymphocytes
Associated Disease N.A.
Mode of Transmission N.A.
VIPR DB link https://www.viprbrc.org/brc/home.spg?decorator=pox
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/74/poxviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Poxviridae

Publication Information

Paper Title Vaccinia virus entry is followed by core activation and proteasome mediated release of the immunomodulatory effector VH1 from lateral bodies
Author's Name Florian Ingo Schmidt, Christopher Karl Ernst Bleck, Lucia Reh, Karel Novy, Bernd Wollscheid, Ari Helenius, Henning Stahlberg and Jason Mercer
Journal Name Cell Reports
Pubmed ID 23891003
Abstract Host cell entry of vaccinia virus, the prototypic poxvirus, involves a membrane fusion event delivering the viral core and two proteinaceous lateral bodies (LBs) into the cytosol. Uncoating of viral cores is poorly characterized, and the composition and function of LBs remains enigmatic. We found that cytosolic cores rapidly dissociated from LBs and expanded in volume, which coincided with reduction of disulfide-bonded core proteins. We identified the abundant phosphoprotein F17, the dual-specificity phosphatase VH1, and the oxidoreductase G4 as bona fide LB components. After reaching the cytosol, F17 was degraded in a proteasome-dependent manner. Proteasome activity, and presumably LB disassembly, was required for the immediate immunomodulatory activity of VH1: dephosphorylation of STAT1 to prevent interferon-gamma-mediated antiviral responses. These results reveal a mechanism used by poxviruses to deliver viral enzymes to the host cell cytosol and are likely to facilitate the identification of additional LB-resident viral effectors.
Used Model HeLa cells
DOI 10.1016/j.celrep.2013.06.028