Hostfactor - VHFIDB

Gene Name	TLR2
HF Protein Name	Toll-like receptor 2
HF Function	Antiviral protein
Uniprot ID	O60603
Protein Sequence	View Fasta Sequence
NCBI Gene ID	7097
Host Factor (HF) Name in Paper	TLR2
Gene synonyms	TIL4
Ensemble Gene ID	ENSG00000137462
Ensemble Transcript	ENST00000260010
KEGG ID	Go to KEGG Database
Gene Ontology ID(s)	GO:0001530, GO:0001666, GO:0001774, GO:0001775, GO:0001875, GO:0002224, GO:0002374, GO:0002755, GO:0004872, GO:0005737, GO:0005794, GO:0005886, GO:0005887, GO:0006691, GO:0006915, GO:0006954, GO:0006955, GO:0007165, GO:0007252, GO:0007612, GO:0008285, GO:0008329, GO:0009636, GO:0009986, GO:0010628, GO:0014005, GO:0030177, GO:0030667, GO:0030670, GO:0031226, GO:0032289, GO:0032570, GO:0032613, GO:0032640, GO:0032722, GO:0032728, GO:0032733, GO:0032735, GO:0032741, GO:0032755, GO:0032757, GO:0032760, GO:0032868, GO:0034123, GO:0034134, GO:0035325, GO:0035354, GO:0038123, GO:0038124, GO:0042346, GO:0042495, GO:0042496, GO:0042497, GO:0042834, GO:0042995, GO:0043312, GO:0044297, GO:0044877, GO:0045087, GO:0045121, GO:0045944, GO:0046209, GO:0046982, GO:0048714, GO:0050729, GO:0050765, GO:0050830, GO:0051092, GO:0051770, GO:0051964, GO:0070542, GO:0071221, GO:0071223, GO:0071726, GO:0071727, GO:2000484,
MINT ID	O60603
STRING	Click to see interaction map
GWAS Analysis	Click to see gwas analysis
OMIM ID	246300
PANTHER ID	PTHR24365:SF17
PDB ID(s)	1FYW, 1FYX, 1O77, 2Z7X, 2Z80,
pfam ID	PF13855, PF01463, PF01582,
Drug Bank ID	DB00045, DB03963, DB05475,
ChEMBL ID	CHEMBL4163
Organism	Homo sapiens (Human)

Virus Name	Vaccinia Virus
Virus Short Name	VACV
Order	Unassigned
Virus Family	Poxviridae
Virus Subfamily	Chordopoxvirinae
Genus	Orthopoxvirus
Species	Vaccinia virus
Host	Human, mammals
Cell Tropism	Dendritic cells, monocytes/macrophages, b lymphocytes, activated t lymphocytes
Associated Disease	N.A.
Mode of Transmission	N.A.
VIPR DB link	https://www.viprbrc.org/brc/home.spg?decorator=pox
ICTV DB link	https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/74/poxviridae
Virus Host DB link	http://www.genome.jp/virushostdb/view/?virus_lineage=Poxviridae

Paper Title	Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-beta
Author's Name	Jiangao Zhu, Jennifer Martinez, Xiaopei Huang and Yiping Yang
Journal Name	Blood
Pubmed ID	16973959
Abstract	Vaccinia virus (VV) has been used extensively as a vaccine vehicle in the clinical application for infectious diseases and cancer. Previous studies have suggested that the unique potency of VV-based vaccine lies in its effective activation of the innate immune system. However, how VV activates innate immune pathways remains largely unknown. In this study, we showed that VV elicited innate immune response through both Toll-like receptor (TLR)-dependent and -independent pathways. The TLR pathway was mediated by TLR2 and MyD88, leading to the production of proinflammatory cytokines, whereas activation of the TLR-independent pathway resulted in the secretion of IFN-beta. More importantly, both TLR-dependent and -independent pathways were required for activating innate and adaptive immunity to VV in vivo. These findings represent the first evidence that innate immune recognition of VV is mediated by TLR2, demonstrate that one pathogen can target both TLR and non-TLR innate immune pathways to work together in achieving efficient activation of host defense, and suggest potential new strategies for the design of effective vaccines.
Used Model	C57BL/6 mice
DOI	10.1182/blood-2006-06-027136

Virus Details