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Virus Details


VHFID9128

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name TYRO3
HF Protein Name Tyrosine-protein kinase receptor TYRO3
HF Function Essential for virus entry
Uniprot ID Q06418
Protein Sequence View Fasta Sequence
NCBI Gene ID 7301
Host Factor (HF) Name in Paper Dtk
Gene synonyms BYK DTK RSE SKY TIF
Ensemble Gene ID ENSG00000092445
Ensemble Transcript ENST00000263798
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0001618, GO:0001779, GO:0004713, GO:0004714, GO:0004716, GO:0005524, GO:0005634, GO:0005635, GO:0005789, GO:0005887, GO:0007155, GO:0007165, GO:0007218, GO:0007283, GO:0014065, GO:0021885, GO:0030168, GO:0032940, GO:0034122, GO:0034446, GO:0042698, GO:0043277, GO:0043491, GO:0043524, GO:0043548, GO:0045824, GO:0046777, GO:0046982, GO:0050728, GO:0051250, GO:0060068, GO:0070050, GO:0070527,
MINT ID Q06418
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 600341
PANTHER ID N.A.
PDB ID(s) 1RHF,
pfam ID PF00041, PF07679, PF07714,
Drug Bank ID ,
ChEMBL ID CHEMBL5314
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Zaire ebolavirus
Virus Short Name ZEBOV
Order Bunyavirales
Virus Family Filoviridae
Virus Subfamily N.A.
Genus Ebolavirus
Species Zaire ebolavirus
Host Bats, human and primates
Cell Tropism N.A.
Associated Disease Hemorragic fever
Mode of Transmission Zoonosis, contact with body fluids
VIPR DB link http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=filo
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/negative-sense-rna-viruses-2011/w/negrna_viruses/197/filoviridae
Virus Host DB link N.A.

Publication Information

Paper Title Tyro3 family mediated cell entry of Ebola and Marburg Viruses
Author's Name Masayuki Shimojima, Ayato Takada, Hideki Ebihara, Gabriele Neumann, Kouki Fujioka, Tatsuro Irimura, Steven Jones, Heinz Feldmann and Yoshihiro Kawaoka
Journal Name Journal Of Virology
Pubmed ID 17005688
Abstract Filoviruses, represented by the genera Ebolavirus and Marburgvirus, cause a lethal hemorrhagic fever in humans and in nonhuman primates. Although filovirus can replicate in various tissues or cell types in these animals, the molecular mechanisms of its broad tropism remain poorly understood. Here we show the involvement of members of the Tyro3 receptor tyrosine kinase family-Axl, Dtk, and Mer-in cell entry of filoviruses. Ectopic expression of these family members in lymphoid cells, which otherwise are highly resistant to filovirus infection, enhanced infection by pseudotype viruses carrying filovirus glycoproteins on their envelopes. This enhancement was reduced by antibodies to Tyro3 family members, Gas6 ligand, or soluble ectodomains of the members. Live Ebola viruses infected both Axl- and Dtk-expressing cells more efficiently than control cells. Antibody to Axl inhibited infection of pseudotype viruses in a number of Axl-positive cell lines. These results implicate each Tyro3 family member as a cell entry factor in filovirus infection.
Used Model Vero E6, HT1080, 293, HeLa, COS-7, A549, and 293T cells
DOI 10.1128/JVI.01157-06