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Virus Details


VHFID9132

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name UBC
HF Protein Name Polyubiquitin-C [Cleaved into: Ubiquitin]
HF Function Essential for virus replication
Uniprot ID P0CG48
Protein Sequence View Fasta Sequence
NCBI Gene ID 7316
Host Factor (HF) Name in Paper UBC
Gene synonyms N.A.
Ensemble Gene ID ENSG00000150991
Ensemble Transcript ENST00000339647;ENST00000536769
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000086, GO:0000122, GO:0000165, GO:0000187, GO:0000209, GO:0000715, GO:0000717, GO:0002020, GO:0002223, GO:0002755, GO:0002756, GO:0003723, GO:0005615, GO:0005634, GO:0005654, GO:0005741, GO:0005789, GO:0005829, GO:0005886, GO:0005978, GO:0006283, GO:0006294, GO:0006296, GO:0006297, GO:0006457, GO:0006879, GO:0006977, GO:0007179, GO:0007219, GO:0007249, GO:0007254, GO:0008543, GO:0010008, GO:0010803, GO:0010972, GO:0016055, GO:0016197, GO:0016236, GO:0016567, GO:0016579, GO:0019058, GO:0019068, GO:0019221, GO:0019985, GO:0030512, GO:0030666, GO:0031145, GO:0031146, GO:0031982, GO:0032479, GO:0032480, GO:0033209, GO:0033683, GO:0034220, GO:0035635, GO:0035666, GO:0036297, GO:0038061, GO:0038095, GO:0038128, GO:0042059, GO:0042276, GO:0042769, GO:0043065, GO:0043066, GO:0043123, GO:0043161, GO:0043209, GO:0043488, GO:0043657, GO:0044267, GO:0044322, GO:0045087, GO:0045742, GO:0045746, GO:0045944, GO:0050852, GO:0051092, GO:0051403, GO:0051436, GO:0051437, GO:0055085, GO:0060071, GO:0,
MINT ID P0CG48
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 191340
PANTHER ID N.A.
PDB ID(s) 1C3T, 1CMX, 1D3Z, 1F9J, 1FXT, 1G6J, 1GJZ, 1NBF, 1OGW, 1Q5W, 1S1Q, 1SIF, 1TBE, 1UBI, 1UBQ, 1UD7, 1XD3, 1XQQ, 1YX5, 1YX6, 1ZGU, 1ZO6, 2AYO, 2BGF, 2DEN, 2FUH, 2G45, 2GBJ, 2GBK, 2GBM, 2GBN, 2GBR, 2GMI, 2HTH, 2IBI, 2J7Q, 2JF5, 2JRI, 2JY6, 2JZZ, 2K25, 2K6D, 2K8B, 2K8C, 2KDF, 2KHW, 2KJH, 2KLG, 2KN5, 2KX0, 2L3Z, 2LD9, 2LVO, 2LVP, 2LVQ, 2LZ6, 2MBO, 2MBQ, 2MCN, 2MI8, 2MJ5, 2MOR, 2MRE, 2MWS, 2N2K, 2NR2, 2O6V, 2OJR, 2PE9, 2PEA, 2RR9, 2RU6, 2W9N, 2WDT, 2XEW, 2Y5B, 2Z59, 2ZCB, 2ZVN, 2ZVO, 3A33, 3ALB, 3AUL, 3B08, 3B0A, 3BY4, 3C0R, 3DVG, 3DVN, 3EEC, 3EFU, 3EHV, 3H7P, 3H7S, 3HM3, 3I3T, 3IFW, 3IHP, 3JSV, 3JVZ, 3JW0, 3K9O, 3K9P, 3KVF, 3KW5, 3LDZ, 3MHS, 3MTN, 3N30, 3N32, 3N3K, 3NS8, 3O65, 3OFI, 3OJ3, 3OJ4, 3ONS, 3PRM, 3PT2, 3PTF, 3Q3F, 3RUL, 3TMP, 3U30, 3UGB, 3V6C, 3V6E, 3VFK, 3VUW, 3VUX, 3VUY, 3WXE, 3WXF, 3ZLZ, 3ZNH, 3ZNI, 3ZNZ, 4AP4, 4AUQ, 4BOS, 4BOZ, 4BVU, 4DDG, 4DDI, 4DHJ, 4DHZ, 4FJV, 4HK2, 4HXD, 4I6L, 4I6N, 4IG7, 4IUM, 4JQW, 4K1R, 4K7S, 4K7U, 4K7W, 4KSK, 4KSL, 4LCD, 4LDT, 4MDK, 4MM3, 4MSM, 4MSQ, 4NQK, 4UN2, 4V3K, 4V3L, 4WZP, 4XOK, 4XOL, 4ZQS, 5A5B, 5AF4, 5AF5, 5AF6, 5AIT, 5AIU, 5B83, 5C7J, 5C7M, 5E6J, 5H07, 5NL4, 5NLF, 5NLI, 5NMC, 5OE7, 5OHV, 5OXH, 5OXI, 5UDH, 5WQ4, 6EQI,
pfam ID PF00240,
Drug Bank ID DB04464,
ChEMBL ID N.A.
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Zaire ebolavirus
Virus Short Name ZEBOV
Order Bunyavirales
Virus Family Filoviridae
Virus Subfamily N.A.
Genus Ebolavirus
Species Zaire ebolavirus
Host Bats, human and primates
Cell Tropism N.A.
Associated Disease Hemorragic fever
Mode of Transmission Zoonosis, contact with body fluids
VIPR DB link http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=filo
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/negative-sense-rna-viruses-2011/w/negrna_viruses/197/filoviridae
Virus Host DB link N.A.

Publication Information

Paper Title Identification of essential filovirion associated host factors by serial proteomic analysis and RNAi screen
Author's Name Kevin B. Spurgers, Tim Alefantis, Brian D. Peyser, Gordon T. Ruthel, Alison A. Bergeron, Julie A. Costantino, Sven Enterlein, Krishna P. Kota, R. C. Dutch Boltz, M. Javad Aman, Vito G. DelVecchio and Sina Bavari
Journal Name Molecular and Cellular Proteomics
Pubmed ID 20702783
Abstract An assessment of the total protein composition of filovirus (ebolavirus and marburgvirus) virions is currently lacking. In this study, liquid chromatography-linked tandem mass spectrometry of purified ebola and marburg virions was performed to identify associated cellular proteins. Host proteins involved in cell adhesion, cytoskeleton, cell signaling, intracellular trafficking, membrane organization, and chaperones were identified. Significant overlap exists between this data set and proteomic studies of disparate viruses, including HIV-1 and influenza A, generated in multiple cell types. However, the great majority of proteins identified here have not been previously described to be incorporated within filovirus particles. Host proteins identified by liquid chromatography-linked tandem mass spectrometry could lack biological relevance because they represent protein contaminants in the virus preparation, or because they are incorporated within virions by chance. These issues were addressed using siRNA library-mediated gene knockdown (targeting each identified virion-associated host protein), followed by filovirus infection. Knockdown of several host proteins (e.g. HSPA5 and RPL18) significantly interfered with ebolavirus and marburgvirus infection, suggesting specific and relevant virion incorporation. Notably, select siRNAs inhibited ebolavirus, but enhanced marburgvirus infection, suggesting important differences between the two viruses. The proteomic analysis presented here contributes to a greater understanding of filovirus biology and potentially identifies host factors that can be targeted for antiviral drug development.
Used Model 293T cells
DOI 10.1074/mcp.M110.003418