| Gene Name | RSAD2 |
| HF Protein Name | Radical S-adenosyl methionine domain-containing protein 2 |
| HF Function | Host restriction factor |
| Uniprot ID | Q8WXG1 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 91543 |
| Host Factor (HF) Name in Paper | RSAD2 |
| Gene synonyms | CIG5 |
| Ensemble Gene ID | ENSG00000134321 |
| Ensemble Transcript | ENST00000382040 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0001650, GO:0003824, GO:0005739, GO:0005741, GO:0005743, GO:0005783, GO:0005789, GO:0005794, GO:0005811, GO:0009615, GO:0016032, GO:0034157, GO:0034165, GO:0035710, GO:0043367, GO:0043621, GO:0045071, GO:0046872, GO:0050709, GO:0051539, GO:0051607, GO:0060337, GO:2000553, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 607810 |
| PANTHER ID | N.A. |
| PDB ID(s) | N.A., |
| pfam ID | PF04055, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Zika virus |
| Virus Short Name | ZIKV |
| Order | Unassigned |
| Virus Family | Flaviviridae |
| Virus Subfamily | N.A. |
| Genus | Flavivirus |
| Species | Zika virus |
| Host | Human, mammals, mosquitoes and ticks |
| Cell Tropism | N.A. |
| Associated Disease | Zika fever |
| Mode of Transmission | Arthropod bite, mainly mosquitoes |
| VIPR DB link | http://www.viprbrc.org/brc/home.spg?decorator=flavi |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/flaviviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Flaviviridae |
| Paper Title | Viperin is an important host restriction factor in control of Zika virus infection |
| Author's Name | Kylie H. Van der Hoek, Nicholas S. Eyre, Byron Shue, Onruedee Khantisitthiporn, Kittirat Glab-Ampi, Jillian M. Carr, Matthew J. Gartner, Lachlan A. Jolly, Paul Q. Thomas, Fatwa Adikusuma, Tanja Jankovic-Karasoulos, Claire T. Roberts, Karla J. Helbig & Michael R. Beard |
| Journal Name | scintific report |
| Pubmed ID | 28667332 |
| Abstract | Zika virus (ZIKV) infection has emerged as a global health threat and infection of pregnant women causes intrauterine growth restriction, spontaneous abortion and microcephaly in newborns. Here we show using biologically relevant cells of neural and placental origin that following ZIKV infection, there is attenuation of the cellular innate response characterised by reduced expression of IFN-beta and associated interferon stimulated genes (ISGs). One such ISG is viperin that has well documented antiviral activity against a wide range of viruses. Expression of viperin in cultured cells resulted in significant impairment of ZIKV replication, while MEFs derived from CRISPR/Cas9 derived viperin-/- mice replicated ZIKV to higher titers compared to their WT counterparts. These results suggest that ZIKV can attenuate ISG expression to avoid the cellular antiviral innate response, thus allowing the virus to replicate unchecked. Moreover, we have identified that the ISG viperin has significant anti-ZIKV activity. Further understanding of how ZIKV perturbs the ISG response and the molecular mechanisms utilised by viperin to suppress ZIKV replication will aid in our understanding of ZIKV biology, pathogenesis and possible design of novel antiviral strategies. |
| Used Model | Huh-7 cells |
| DOI | 10.1038/s41598-017-04138-1 |
