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Virus Details


VHFID9217

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name GRIN3A
HF Protein Name Glutamate receptor ionotropic, NMDA 3A
HF Function Essential for virus infection
Uniprot ID Q8TCU5
Protein Sequence View Fasta Sequence
NCBI Gene ID 116443
Host Factor (HF) Name in Paper GRIN3A
Gene synonyms KIAA1973
Ensemble Gene ID ENSG00000198785
Ensemble Transcript ENST00000361820
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0004972, GO:0005234, GO:0005262, GO:0006816, GO:0014069, GO:0016020, GO:0016021, GO:0016358, GO:0016594, GO:0017146, GO:0030054, GO:0042802, GO:0043005, GO:0043025, GO:0045202, GO:0045211, GO:0045471, GO:0051721, GO:0060134,
MINT ID N.A.
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 606650
PANTHER ID N.A.
PDB ID(s) N.A.,
pfam ID PF00060, PF10613,
Drug Bank ID DB00659, DB06151, DB00915, DB00289, DB01161, DB00514, DB00898, DB00392, DB00949, DB00996, DB06741, DB01159, DB01221, DB06738, DB00142, DB01043, DB00333, DB04896, DB04926, DB01173, DB00312, DB03575, DB01174, DB01708, DB00721, DB01549, DB00418, DB01520, DB00193,
ChEMBL ID CHEMBL4787
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Zika virus
Virus Short Name ZIKV
Order Unassigned
Virus Family Flaviviridae
Virus Subfamily N.A.
Genus Flavivirus
Species Zika virus
Host Human, mammals, mosquitoes and ticks
Cell Tropism N.A.
Associated Disease Zika fever
Mode of Transmission Arthropod bite, mainly mosquitoes
VIPR DB link http://www.viprbrc.org/brc/home.spg?decorator=flavi
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/flaviviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Flaviviridae

Publication Information

Paper Title Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics
Author's Name George Savidis, William M. McDougall, Paul Meraner, Jill M. Perreira, Jocelyn M. Portmann, Gaia Trincucci, Sinu P. John, Aaron M. Aker, Nicholas Renzette, Douglas R. Robbins, Zhiru Guo, Sharone Green, Timothy F. Kowalik, Abraham L. Brass
Journal Name Cell Reports
Pubmed ID 27342126
Abstract The flaviviruses dengue virus (DENV) and Zika virus (ZIKV) are severe health threats with rapidly expanding ranges. To identify the host cell dependencies of DENV and ZIKV, we completed orthologous functional genomic screens using RNAi and CRISPR/Cas9 approaches. The screens recovered the ZIKV entry factor AXL as well as multiple host factors involved in endocytosis (RAB5C and RABGEF), heparin sulfation (NDST1 and EXT1), and transmembrane protein processing and maturation, including the endoplasmic reticulum membrane complex (EMC). We find that both flaviviruses require the EMC for their early stages of infection. Together, these studies generate a high-confidence, systems-wide view of human-flavivirus interactions and provide insights into the role of the EMC in flavivirus replication.
Used Model HeLa cells
DOI 10.1016/j.celrep.2016.06.028