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Virus Details


VHFID9218

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name MEN1
HF Protein Name Menin
HF Function Essential for virus infection
Uniprot ID O00255
Protein Sequence View Fasta Sequence
NCBI Gene ID 4221
Host Factor (HF) Name in Paper MEN1
Gene synonyms SCG2
Ensemble Gene ID ENSG00000133895
Ensemble Transcript ENST00000312049 [O00255-2];ENST00000315422 [O00255-2];ENST00000337652 [O00255-1];ENST00000377313 [O00255-1];ENST00000377321 [O00255-3];ENST00000377326 [O00255-2];ENST00000394374 [O00255-1];ENST00000394376 [O00255-1]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000122, GO:0000165, GO:0000278, GO:0000400, GO:0000403, GO:0000784, GO:0000785, GO:0000790, GO:0001933, GO:0002076, GO:0003309, GO:0003682, GO:0003690, GO:0005634, GO:0005654, GO:0005737, GO:0005788, GO:0005829, GO:0006281, GO:0006351, GO:0006974, GO:0007420, GO:0008285, GO:0009411, GO:0010332, GO:0010812, GO:0016363, GO:0030511, GO:0030674, GO:0032092, GO:0032154, GO:0032925, GO:0032991, GO:0034968, GO:0035097, GO:0043433, GO:0043687, GO:0044212, GO:0044267, GO:0045668, GO:0045736, GO:0045786, GO:0045892, GO:0045944, GO:0046329, GO:0046697, GO:0047485, GO:0050680, GO:0051974, GO:0061469, GO:0070412, GO:0071333, GO:0071375, GO:0071559, GO:1902807, GO:1904837,
MINT ID O00255
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 131100
PANTHER ID PTHR12693
PDB ID(s) 3U84, 3U85, 3U86, 3U88, 4GPQ, 4GQ3, 4GQ4, 4GQ6, 4I80, 4OG3, 4OG4, 4OG5, 4OG6, 4OG7, 4OG8, 4X5Y, 4X5Z, 5DB0, 5DB1, 5DB2, 5DB3, 5DD9, 5DDA, 5DDB, 5DDC, 5DDD, 5DDE, 5DDF, 6B41,
pfam ID PF05053,
Drug Bank ID N.A.,
ChEMBL ID CHEMBL1615381
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Zika virus
Virus Short Name ZIKV
Order Unassigned
Virus Family Flaviviridae
Virus Subfamily N.A.
Genus Flavivirus
Species Zika virus
Host Human, mammals, mosquitoes and ticks
Cell Tropism N.A.
Associated Disease Zika fever
Mode of Transmission Arthropod bite, mainly mosquitoes
VIPR DB link http://www.viprbrc.org/brc/home.spg?decorator=flavi
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/flaviviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Flaviviridae

Publication Information

Paper Title Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics
Author's Name George Savidis, William M. McDougall, Paul Meraner, Jill M. Perreira, Jocelyn M. Portmann, Gaia Trincucci, Sinu P. John, Aaron M. Aker, Nicholas Renzette, Douglas R. Robbins, Zhiru Guo, Sharone Green, Timothy F. Kowalik, Abraham L. Brass
Journal Name Cell Reports
Pubmed ID 27342126
Abstract The flaviviruses dengue virus (DENV) and Zika virus (ZIKV) are severe health threats with rapidly expanding ranges. To identify the host cell dependencies of DENV and ZIKV, we completed orthologous functional genomic screens using RNAi and CRISPR/Cas9 approaches. The screens recovered the ZIKV entry factor AXL as well as multiple host factors involved in endocytosis (RAB5C and RABGEF), heparin sulfation (NDST1 and EXT1), and transmembrane protein processing and maturation, including the endoplasmic reticulum membrane complex (EMC). We find that both flaviviruses require the EMC for their early stages of infection. Together, these studies generate a high-confidence, systems-wide view of human-flavivirus interactions and provide insights into the role of the EMC in flavivirus replication.
Used Model HeLa cells
DOI 10.1016/j.celrep.2016.06.028