| Gene Name | SLC9A3 |
| HF Protein Name | Sodium/hydrogen exchanger 3 |
| HF Function | Essential for virus infection |
| Uniprot ID | P48764 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 6550 |
| Host Factor (HF) Name in Paper | SLC9A3 |
| Gene synonyms | NHE3 |
| Ensemble Gene ID | ENSG00000066230 |
| Ensemble Transcript | ENST00000264938 [P48764-1];ENST00000514375 [P48764-2] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0005886, GO:0005903, GO:0006811, GO:0009986, GO:0015385, GO:0015386, GO:0016021, GO:0016324, GO:0030165, GO:0031526, GO:0051453, GO:0070062, GO:0071805, GO:0098719, |
| MINT ID | P48764 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 182307 |
| PANTHER ID | PTHR10110 |
| PDB ID(s) | N.A., |
| pfam ID | PF00999, |
| Drug Bank ID | N.A., |
| ChEMBL ID | CHEMBL3273 |
| Organism | Homo sapiens (Human) |
| Virus Name | Zika virus |
| Virus Short Name | ZIKV |
| Order | Unassigned |
| Virus Family | Flaviviridae |
| Virus Subfamily | N.A. |
| Genus | Flavivirus |
| Species | Zika virus |
| Host | Human, mammals, mosquitoes and ticks |
| Cell Tropism | N.A. |
| Associated Disease | Zika fever |
| Mode of Transmission | Arthropod bite, mainly mosquitoes |
| VIPR DB link | http://www.viprbrc.org/brc/home.spg?decorator=flavi |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/flaviviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Flaviviridae |
| Paper Title | Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics |
| Author's Name | George Savidis, William M. McDougall, Paul Meraner, Jill M. Perreira, Jocelyn M. Portmann, Gaia Trincucci, Sinu P. John, Aaron M. Aker, Nicholas Renzette, Douglas R. Robbins, Zhiru Guo, Sharone Green, Timothy F. Kowalik, Abraham L. Brass |
| Journal Name | Cell Reports |
| Pubmed ID | 27342126 |
| Abstract | The flaviviruses dengue virus (DENV) and Zika virus (ZIKV) are severe health threats with rapidly expanding ranges. To identify the host cell dependencies of DENV and ZIKV, we completed orthologous functional genomic screens using RNAi and CRISPR/Cas9 approaches. The screens recovered the ZIKV entry factor AXL as well as multiple host factors involved in endocytosis (RAB5C and RABGEF), heparin sulfation (NDST1 and EXT1), and transmembrane protein processing and maturation, including the endoplasmic reticulum membrane complex (EMC). We find that both flaviviruses require the EMC for their early stages of infection. Together, these studies generate a high-confidence, systems-wide view of human-flavivirus interactions and provide insights into the role of the EMC in flavivirus replication. |
| Used Model | HeLa cells |
| DOI | 10.1016/j.celrep.2016.06.028 |
